All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Thu 3:25 PM ET.
| Rank | Player | Match |
| 1 | Saquon Barkley | NYG @ GB |
| 2 | Derrick Henry | Ten @ Wsh |
| 3 | Austin Ekeler | LAC @ Cle |
| 4 | Christian McCaffrey | Car vs SF |
| 5 | Nick Chubb | Cle vs LAC |
| 6 | Leonard Fournette | TB vs Atl |
| 7 | Dalvin Cook | Min vs Chi |
| 8 | Joe Mixon | Cin @ Bal |
| 9 | Aaron Jones | GB vs NYG |
| 10 | Josh Jacobs | LV @ KC |
| 11 | James Robinson | Jax vs Hou |
| 12 | Miles Sanders | Phi @ Ari |
| 13 | Jamaal Williams | Det @ NE |
| 14 | Breece Hall | NYJ vs Mia |
| 15 | Dameon Pierce | Hou @ Jax |
| 16 | Alvin Kamara (GTD) | NO vs Sea |
| 17 | Jeff Wilson | SF @ Car |
| 18 | Damien Harris | NE vs Det |
| 19 | J.K. Dobbins (GTD) | Bal vs Cin |
| 20 | James Conner | Ari vs Phi |
| Rank | Player | Match |
| 21 | Najee Harris | Pit @ Buf |
| 22 | Clyde Edwards-Helaire | KC vs LV |
| 23 | Melvin Gordon | Den vs Ind |
| 24 | A.J. Dillon | GB vs NYG |
| 25 | Rhamondre Stevenson | NE vs Det |
| 26 | Rashaad Penny | Sea @ NO |
| 27 | Nyheim Hines | Ind @ Den |
| 28 | Devin Singletary | Buf vs Pit |
| 29 | D`Andre Swift | Det @ NE |
| 30 | Kareem Hunt | Cle vs LAC |
| 31 | Ezekiel Elliott | Dal @ LAR |
| 32 | Antonio Gibson | Wsh vs Ten |
| 33 | Khalil Herbert | Chi @ Min |
| 34 | David Montgomery (GTD) | Chi @ Min |
| 35 | Travis Etienne | Jax vs Hou |
| 36 | Cam Akers | LAR vs Dal |
| 37 | Raheem Mostert | Mia @ NYJ |
| 38 | Tyler Allgeier | Atl @ TB |
| 39 | Chase Edmonds | Mia @ NYJ |
| 40 | Darrell Henderson | LAR vs Dal |
