All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sun 9:08 AM ET.
| Rank | Player | Match |
| 1 | Jonathan Taylor | Ind @ Hou |
| 2 | Christian McCaffrey | Car vs Cle |
| 3 | Derrick Henry | Ten vs NYG |
| 4 | Austin Ekeler | LAC vs LV |
| 5 | Alvin Kamara | NO @ Atl |
| 6 | Joe Mixon | Cin vs Pit |
| 7 | Dalvin Cook | Min vs GB |
| 8 | Najee Harris | Pit @ Cin |
| 9 | Aaron Jones | GB @ Min |
| 10 | D'Andre Swift | Det vs Phi |
| 11 | Saquon Barkley | NYG @ Ten |
| 12 | Leonard Fournette | TB @ Dal |
| 13 | James Conner | Ari vs KC |
| 14 | Javonte Williams | Den @ Sea |
| 15 | Nick Chubb | Cle @ Car |
| 16 | Antonio Gibson | Wsh vs Jax |
| 17 | Travis Etienne | Jax @ Wsh |
| 18 | Ezekiel Elliott | Dal vs TB |
| 19 | Rashaad Penny | Sea vs Den |
| 20 | Chase Edmonds | Mia vs NE |
| Rank | Player | Match |
| 21 | Eli Mitchell | SF @ Chi |
| 22 | David Montgomery | Chi vs SF |
| 23 | Josh Jacobs | LV @ LAC |
| 24 | Dameon Pierce | Hou vs Ind |
| 25 | Clyde Edwards-Helaire | KC @ Ari |
| 26 | J.K. Dobbins (GTD) | Bal @ NYJ |
| 27 | A.J. Dillon | GB @ Min |
| 28 | Miles Sanders | Phi @ Det |
| 29 | Tony Pollard | Dal vs TB |
| 30 | Cordarrelle Patterson | Atl vs NO |
| 31 | Damien Harris | NE @ Mia |
| 32 | Rhamondre Stevenson | NE @ Mia |
| 33 | Breece Hall | NYJ vs Bal |
| 34 | Kareem Hunt | Cle @ Car |
| 35 | Melvin Gordon | Den @ Sea |
| 36 | Michael Carter | NYJ vs Bal |
| 37 | Raheem Mostert | Mia vs NE |
| 38 | Nyheim Hines | Ind @ Hou |
| 39 | J.D. McKissic | Wsh vs Jax |
| 40 | Rex Burkhead | Hou vs Ind |
