All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sat 11:23 AM ET.
| Rank | Player | Match |
| 1 | Jahmyr Gibbs | Det vs Min |
| 2 | Bijan Robinson | Atl @ TB |
| 3 | Kenneth Walker III | KC @ Den |
| 4 | Derrick Henry | Bal @ Buf |
| 5 | Javonte Williams | Dal vs Ari |
| 6 | Kyren Williams | LAR vs LAC |
| 7 | James Cook | Buf vs Bal |
| 8 | Chase Brown | Cin vs Ten |
| 9 | Bucky Irving | TB vs Atl |
| 10 | Jonathan Taylor | Ind @ Jax |
| 11 | Jaylen Warren | Pit vs Cle |
| 12 | Bhayshul Tuten | Jax vs Ind |
| 13 | Ashton Jeanty | LV @ NYJ |
| 14 | Tony Pollard | Ten @ Cin |
| 15 | Rhamondre Stevenson | NE @ Mia |
| 16 | D'Andre Swift | Chi @ Sea |
| 17 | Breece Hall (Q) | NYJ vs LV |
| 18 | Saquon Barkley | Phi @ Wsh |
| 19 | Ollie Gordon | Mia vs NE |
| 20 | Quinshon Judkins | Cle @ Pit |
| Rank | Player | Match |
| 21 | Rachaad White | Wsh vs Phi |
| 22 | Jordan Mason | Min @ Det |
| 23 | Omarion Hampton | LAC @ LAR |
| 24 | Jonah Coleman | Den vs KC |
| 25 | Braelon Allen | NYJ vs LV |
| 26 | Zach Charbonnet (Q) | Sea vs Chi |
| 27 | Jeremiyah Love | Ari @ Dal |
| 28 | Blake Corum | LAR vs LAC |
| 29 | Rico Dowdle | Pit vs Cle |
| 30 | Aaron Jones | Min @ Det |
| 31 | Kenneth Gainwell (Q) | TB vs Atl |
| 32 | Samaje Perine | Cin vs Ten |
| 33 | J.K. Dobbins | Den vs KC |
| 34 | Chris Rodriguez Jr. | Jax vs Ind |
| 35 | Tyler Allgeier | Ari @ Dal |
| 36 | Dylan Sampson | Cle @ Pit |
| 37 | Kyle Monangai (Q) | Chi @ Sea |
| 38 | Mike Washington | LV @ NYJ |
| 39 | Emanuel Wilson | Sea vs Chi |
| 40 | TreVeyon Henderson (Q) | NE @ Mia |
