All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sat 11:12 AM ET.
| Rank | Player | Match |
| 1 | Jahmyr Gibbs | Det vs NE |
| 2 | Christian McCaffrey | SF @ Dal |
| 3 | Bijan Robinson | Atl vs KC |
| 4 | Kenneth Walker (Q) | KC @ Atl |
| 5 | James Cook | Buf @ NYJ |
| 6 | Derrick Henry | Bal vs LAC |
| 7 | Chuba Hubbard | Car @ NO |
| 8 | Jonathan Taylor | Ind vs Mia |
| 9 | Kyren Williams | LAR @ Ari |
| 10 | Jaylen Warren | Pit @ Cin |
| 11 | Bhayshul Tuten | Jax @ Ten |
| 12 | Javonte Williams | Dal vs SF |
| 13 | Ollie Gordon | Mia @ Ind |
| 14 | Chase Brown | Cin vs Pit |
| 15 | Breece Hall | NYJ vs Buf |
| 16 | Zach Charbonnet | Sea @ LV |
| 17 | Woody Marks | Hou @ Cle |
| 18 | Travis Etienne (IR) | NO vs Car |
| 19 | Tyler Allgeier | Ari vs LAR |
| 20 | Tony Pollard | Ten vs Jax |
| Rank | Player | Match |
| 21 | Quinshon Judkins | Cle vs Hou |
| 22 | Corey Kiner | NE @ Det |
| 23 | NO vs Car | |
| 24 | Blake Corum | LAR @ Ari |
| 25 | Omarion Hampton | LAC @ Bal |
| 26 | Mike Washington | LV vs Sea |
| 27 | Jadarian Price | Sea @ LV |
| 28 | Braelon Allen | NYJ vs Buf |
| 29 | Jordan Mason | Min @ GB |
| 30 | Rico Dowdle | Pit @ Cin |
| 31 | Alvin Kamara | NO vs Car |
| 32 | Ashton Jeanty | LV vs Sea |
| 33 | Aaron Jones | Min @ GB |
| 34 | Dylan Sampson | Cle vs Hou |
| 35 | Chris Rodriguez | Jax @ Ten |
| 36 | Kimani Vidal | LAC @ Bal |
| 37 | Keaton Mitchell (Q) | LAC @ Bal |
| 38 | Bam Knight | Ari vs LAR |
| 39 | Kaelon Black | SF @ Dal |
| 40 | Justice Hill | Bal vs LAC |
