All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Thu 11:54 AM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | SF vs Ten |
| 2 | Jaxon Smith-Njigba | Sea vs Ind |
| 3 | De'Von Achane | Mia @ Pit |
| 4 | Puka Nacua | LAR vs Det |
| 5 | Jahmyr Gibbs | Det @ LAR |
| 6 | Bijan Robinson | Atl @ TB |
| 7 | Ja'Marr Chase | Cin vs Bal |
| 8 | Derrick Henry | Bal @ Cin |
| 9 | Jonathan Taylor | Ind @ Sea |
| 10 | Saquon Barkley | Phi vs LV |
| 11 | Amon-Ra St. Brown | Det @ LAR |
| 12 | James Cook | Buf @ NE |
| 13 | George Pickens | Dal vs Min |
| 14 | Chase Brown | Cin vs Bal |
| 15 | Josh Jacobs | GB @ Den |
| 16 | Nico Collins | Hou vs Ari |
| 17 | Javonte Williams | Dal vs Min |
| 18 | Davante Adams | LAR vs Det |
| 19 | Rashee Rice | KC vs LAC |
| 20 | Woody Marks | Hou vs Ari |
| 21 | Ashton Jeanty | LV @ Phi |
| 22 | Rico Dowdle | Car @ NO |
| 23 | Breece Hall | NYJ @ Jax |
| 24 | Kyren Williams | LAR vs Det |
| 25 | Bucky Irving | TB vs Atl |
| 26 | Chris Olave | NO vs Car |
| 27 | Travis Etienne | Jax vs NYJ |
| 28 | Trey McBride | Ari @ Hou |
| 29 | Quinshon Judkins | Cle @ Chi |
| 30 | A.J. Brown | Phi vs LV |
| 31 | Justin Jefferson | Min @ Dal |
| 32 | Zay Flowers | Bal @ Cin |
| 33 | Jaylen Warren | Pit vs Mia |
| 34 | George Kittle | SF vs Ten |
| 35 | Jameson Williams | Det @ LAR |
| Rank | Player | Match |
| 36 | TreVeyon Henderson | NE vs Buf |
| 37 | Kenneth Walker III | Sea vs Ind |
| 38 | RJ Harvey | Den vs GB |
| 39 | Wan'Dale Robinson | NYG vs Wsh |
| 40 | Tyrone Tracy Jr. | NYG vs Wsh |
| 41 | D'Andre Swift | Chi vs Cle |
| 42 | CeeDee Lamb | Dal vs Min |
| 43 | Tetairoa McMillan | Car @ NO |
| 44 | Jaylen Waddle | Mia @ Pit |
| 45 | DeVonta Smith | Phi vs LV |
| 46 | Michael Wilson | Ari @ Hou |
| 47 | Omarion Hampton | LAC @ KC |
| 48 | Deebo Samuel | Wsh @ NYG |
| 49 | D.K. Metcalf | Pit vs Mia |
| 50 | Jakobi Meyers | Jax vs NYJ |
| 51 | Stefon Diggs | NE vs Buf |
| 52 | Jauan Jennings | SF vs Ten |
| 53 | Devin Neal (Q) | NO vs Car |
| 54 | Kareem Hunt | KC vs LAC |
| 55 | Kenneth Gainwell | Pit vs Mia |
| 56 | Brock Bowers | LV @ Phi |
| 57 | Mike Evans | TB vs Atl |
| 58 | Emeka Egbuka | TB vs Atl |
| 59 | Terry McLaurin | Wsh @ NYG |
| 60 | Brian Thomas Jr. | Jax vs NYJ |
| 61 | David Montgomery | Det @ LAR |
| 62 | Tony Pollard | Ten @ SF |
| 63 | Zach Charbonnet | Sea vs Ind |
| 64 | Courtland Sutton | Den vs GB |
| 65 | Aaron Jones | Min @ Dal |
| 66 | Ladd McConkey | LAC @ KC |
| 67 | Juwan Johnson | NO vs Car |
| 68 | Mark Andrews | Bal @ Cin |
| 69 | Jordan Addison | Min @ Dal |
| 70 | Jayden Higgins | Hou vs Ari |
