All position ranks are: QB WR TE FLEX DEF
These rankings were updated as of Wed 8:20 PM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | SF vs Jax |
| 2 | Jonathan Taylor | Ind @ LAR |
| 3 | Bijan Robinson | Atl vs Wsh |
| 4 | Jahmyr Gibbs | Det vs Cle |
| 5 | Josh Jacobs (Q) | GB @ Dal |
| 6 | De'Von Achane | Mia vs NYJ |
| 7 | James Cook | Buf vs NO |
| 8 | Saquon Barkley | Phi @ TB |
| 9 | Derrick Henry | Bal @ KC |
| 10 | Kyren Williams | LAR vs Ind |
| 11 | Bucky Irving | TB vs Phi |
| 12 | Omarion Hampton | LAC @ NYG |
| 13 | Jordan Mason | Min @ Pit |
| 14 | Chase Brown | Cin @ Den |
| 15 | Alvin Kamara | NO @ Buf |
| 16 | Breece Hall | NYJ @ Mia |
| 17 | Chuba Hubbard | Car @ NE |
| 18 | J.K. Dobbins | Den vs Cin |
| 19 | Ashton Jeanty | LV vs Chi |
| 20 | Quinshon Judkins | Cle @ Det |
| Rank | Player | Match |
| 21 | Tony Pollard | Ten @ Hou |
| 22 | Javonte Williams | Dal vs GB |
| 23 | Cam Skattebo | NYG vs LAC |
| 24 | Jaylen Warren | Pit vs Min |
| 25 | Kenneth Walker III | Sea @ Ari |
| 26 | David Montgomery | Det vs Cle |
| 27 | D'Andre Swift (Q) | Chi @ LV |
| 28 | Trey Benson | Ari vs Sea |
| 29 | Travis Etienne | Jax @ SF |
| 30 | Nick Chubb | Hou vs Ten |
| 31 | Rhamondre Stevenson | NE vs Car |
| 32 | TreVeyon Henderson | NE vs Car |
| 33 | Kareem Hunt | KC vs Bal |
| 34 | Zach Charbonnet (Q) | Sea @ Ari |
| 35 | Jacory Croskey-Merritt (Q) | Wsh @ Atl |
| 36 | Bhayshul Tuten (Q) | Jax @ SF |
| 37 | Isiah Pacheco | KC vs Bal |
| 38 | RJ Harvey | Den vs Cin |
| 39 | Rachaad White | TB vs Phi |
| 40 | Ollie Gordon | Mia vs NYJ |
