All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sat 1:16 AM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | SF vs Jax |
| 2 | Puka Nacua | LAR vs Ind |
| 3 | Bijan Robinson | Atl vs Wsh |
| 4 | Jonathan Taylor | Ind @ LAR |
| 5 | Jahmyr Gibbs | Det vs Cle |
| 6 | Josh Jacobs | GB @ Dal |
| 7 | De'Von Achane | Mia vs NYJ |
| 8 | James Cook | Buf vs NO |
| 9 | Saquon Barkley | Phi @ TB |
| 10 | Amon-Ra St. Brown | Det vs Cle |
| 11 | Kyren Williams | LAR vs Ind |
| 12 | Derrick Henry | Bal @ KC |
| 13 | Nico Collins | Hou vs Ten |
| 14 | Bucky Irving | TB vs Phi |
| 15 | Cam Skattebo | NYG vs LAC |
| 16 | Davante Adams (Q) | LAR vs Ind |
| 17 | Justin Jefferson | Min @ Pit |
| 18 | Ja'Marr Chase | Cin @ Den |
| 19 | Jordan Mason | Min @ Pit |
| 20 | Malik Nabers | NYG vs LAC |
| 21 | Omarion Hampton | LAC @ NYG |
| 22 | Chase Brown | Cin @ Den |
| 23 | Courtland Sutton | Den vs Cin |
| 24 | Tyreek Hill | Mia vs NYJ |
| 25 | Breece Hall | NYJ @ Mia |
| 26 | Alvin Kamara | NO @ Buf |
| 27 | J.K. Dobbins | Den vs Cin |
| 28 | Chuba Hubbard (Q) | Car @ NE |
| 29 | Ashton Jeanty | LV vs Chi |
| 30 | Quinshon Judkins | Cle @ Det |
| 31 | George Pickens | Dal vs GB |
| 32 | Tony Pollard | Ten @ Hou |
| 33 | A.J. Brown | Phi @ TB |
| 34 | Javonte Williams | Dal vs GB |
| 35 | Jaylen Warren (Q) | Pit vs Min |
| Rank | Player | Match |
| 36 | D'Andre Swift (Q) | Chi @ LV |
| 37 | Ricky Pearsall (Q) | SF vs Jax |
| 38 | David Montgomery | Det vs Cle |
| 39 | Garrett Wilson | NYJ @ Mia |
| 40 | Ladd McConkey | LAC @ NYG |
| 41 | Keenan Allen | LAC @ NYG |
| 42 | Drake London | Atl vs Wsh |
| 43 | Rome Odunze | Chi @ LV |
| 44 | Emeka Egbuka | TB vs Phi |
| 45 | Michael Pittman Jr. | Ind @ LAR |
| 46 | Jakobi Meyers | LV vs Chi |
| 47 | Brock Bowers | LV vs Chi |
| 48 | Brian Thomas Jr. | Jax @ SF |
| 49 | DeVonta Smith | Phi @ TB |
| 50 | Travis Etienne | Jax @ SF |
| 51 | Zay Flowers | Bal @ KC |
| 52 | DJ Moore | Chi @ LV |
| 53 | Tucker Kraft | GB @ Dal |
| 54 | Deebo Samuel | Wsh @ Atl |
| 55 | Tetairoa McMillan (Q) | Car @ NE |
| 56 | Nick Chubb | Hou vs Ten |
| 57 | Jameson Williams | Det vs Cle |
| 58 | Jordan Addison | Min @ Pit |
| 59 | Xavier Worthy | KC vs Bal |
| 60 | Tyler Warren | Ind @ LAR |
| 61 | Tee Higgins | Cin @ Den |
| 62 | Jaylen Waddle (P) | Mia vs NYJ |
| 63 | Quentin Johnston | LAC @ NYG |
| 64 | D.K. Metcalf | Pit vs Min |
| 65 | Jerry Jeudy | Cle @ Det |
| 66 | Sam LaPorta | Det vs Cle |
| 67 | Hunter Henry | NE vs Car |
| 68 | Rhamondre Stevenson | NE vs Car |
| 69 | Chris Olave | NO @ Buf |
| 70 | Jauan Jennings (Q) | SF vs Jax |
