All position ranks are: QB RB TE FLEX DEF
These rankings were updated as of Wed 8:20 PM ET.
| Rank | Player | Match |
| 1 | Puka Nacua | LAR vs Ind |
| 2 | Amon-Ra St. Brown | Det vs Cle |
| 3 | Nico Collins (Q) | Hou vs Ten |
| 4 | Ja'Marr Chase | Cin @ Den |
| 5 | Malik Nabers (Q) | NYG vs LAC |
| 6 | Justin Jefferson | Min @ Pit |
| 7 | Davante Adams | LAR vs Ind |
| 8 | Jaxon Smith-Njigba | Sea @ Ari |
| 9 | George Pickens | Dal vs GB |
| 10 | Courtland Sutton | Den vs Cin |
| 11 | Tyreek Hill | Mia vs NYJ |
| 12 | A.J. Brown | Phi @ TB |
| 13 | Garrett Wilson | NYJ @ Mia |
| 14 | Ricky Pearsall (Q) | SF vs Jax |
| 15 | Ladd McConkey | LAC @ NYG |
| 16 | Drake London | Atl vs Wsh |
| 17 | Brian Thomas Jr. (P) | Jax @ SF |
| 18 | Emeka Egbuka | TB vs Phi |
| 19 | Rome Odunze | Chi @ LV |
| 20 | Zay Flowers | Bal @ KC |
| 21 | Tetairoa McMillan (Q) | Car @ NE |
| 22 | Keenan Allen | LAC @ NYG |
| 23 | Jakobi Meyers | LV vs Chi |
| 24 | Michael Pittman Jr. | Ind @ LAR |
| 25 | DeVonta Smith | Phi @ TB |
| Rank | Player | Match |
| 26 | Jameson Williams | Det vs Cle |
| 27 | Deebo Samuel | Wsh @ Atl |
| 28 | DJ Moore | Chi @ LV |
| 29 | Jerry Jeudy | Cle @ Det |
| 30 | D.K. Metcalf | Pit vs Min |
| 31 | Marvin Harrison Jr. | Ari vs Sea |
| 32 | Tee Higgins | Cin @ Den |
| 33 | Chris Olave | NO @ Buf |
| 34 | Jordan Addison | Min @ Pit |
| 35 | Jaylen Waddle | Mia vs NYJ |
| 36 | Quentin Johnston | LAC @ NYG |
| 37 | Jauan Jennings (Q) | SF vs Jax |
| 38 | Keon Coleman | Buf vs NO |
| 39 | Khalil Shakir | Buf vs NO |
| 40 | Matthew Golden | GB @ Dal |
| 41 | Cooper Kupp | Sea @ Ari |
| 42 | Calvin Ridley | Ten @ Hou |
| 43 | Romeo Doubs | GB @ Dal |
| 44 | Marquise Brown (P) | KC vs Bal |
| 45 | Wan'Dale Robinson | NYG vs LAC |
| 46 | Stefon Diggs | NE vs Car |
| 47 | Rashid Shaheed | NO @ Buf |
| 48 | Darnell Mooney | Atl vs Wsh |
| 49 | Christian Kirk | Hou vs Ten |
| 50 | Tre Tucker | LV vs Chi |
