All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Thu 12:03 PM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey (Q) | SF @ GB |
| 2 | De'Von Achane | Mia vs NE |
| 3 | Joe Mixon | Hou vs Ten |
| 4 | Saquon Barkley | Phi @ LAR |
| 5 | Derrick Henry | Bal @ LAC |
| 6 | Amon-Ra St. Brown | Det vs Chi |
| 7 | Jahmyr Gibbs | Det vs Chi |
| 8 | Kenneth Walker III | Sea vs Ari |
| 9 | Kyren Williams | LAR vs Phi |
| 10 | Justin Jefferson | Min @ Chi |
| 11 | Josh Jacobs (Q) | GB vs SF |
| 12 | Jonathan Taylor | Ind vs Det |
| 13 | Nico Collins | Hou vs Ten |
| 14 | A.J. Brown | Phi @ LAR |
| 15 | James Conner | Ari @ Sea |
| 16 | CeeDee Lamb (Q) | Dal @ Wsh |
| 17 | Tyreek Hill (Q) | Mia vs NE |
| 18 | Puka Nacua | LAR vs Phi |
| 19 | DK Metcalf | Sea vs Ari |
| 20 | Cooper Kupp | LAR vs Phi |
| 21 | David Montgomery | Det vs Chi |
| 22 | Aaron Jones (P) | Min @ Chi |
| 23 | Terry McLaurin | Wsh vs Dal |
| 24 | Travis Kelce | KC @ Car |
| 25 | Mike Evans (Q) | TB @ NYG |
| 26 | J.K. Dobbins | LAC vs Bal |
| 27 | Malik Nabers | NYG vs TB |
| 28 | Brian Robinson | Wsh vs Dal |
| 29 | Ladd McConkey | LAC vs Bal |
| 30 | Rhamondre Stevenson | NE @ Mia |
| 31 | D'Andre Swift (Q) | Chi vs Min |
| 32 | George Pickens | Pit @ Cle |
| 33 | Jaxon Smith-Njigba | Sea vs Ari |
| 34 | Brock Bowers | LV vs Den |
| 35 | Tyrone Tracy Jr. | NYG vs TB |
| Rank | Player | Match |
| 36 | Jauan Jennings | SF @ GB |
| 37 | Zay Flowers | Bal @ LAC |
| 38 | Deebo Samuel | SF @ GB |
| 39 | Najee Harris | Pit @ Cle |
| 40 | Tony Pollard | Ten @ Hou |
| 41 | Chuba Hubbard | Car vs KC |
| 42 | Trey McBride | Ari @ Sea |
| 43 | Jayden Reed | GB vs SF |
| 44 | Marvin Harrison Jr. | Ari @ Sea |
| 45 | DeVonta Smith (Q) | Phi @ LAR |
| 46 | Courtland Sutton | Den @ LV |
| 47 | Bucky Irving (P) | TB @ NYG |
| 48 | Rico Dowdle | Dal @ Wsh |
| 49 | Josh Downs | Ind vs Det |
| 50 | Rachaad White | TB @ NYG |
| 51 | Calvin Ridley (Q) | Ten @ Hou |
| 52 | Tank Dell | Hou vs Ten |
| 53 | George Kittle (Q) | SF @ GB |
| 54 | Jakobi Meyers | LV vs Den |
| 55 | Nick Chubb | Cle vs Pit |
| 56 | Kareem Hunt (P) | KC @ Car |
| 57 | Jameson Williams | Det vs Chi |
| 58 | Austin Ekeler | Wsh vs Dal |
| 59 | David Njoku | Cle vs Pit |
| 60 | DeAndre Hopkins | KC @ Car |
| 61 | Quentin Johnston | LAC vs Bal |
| 62 | DJ Moore | Chi vs Min |
| 63 | Cedric Tillman | Cle vs Pit |
| 64 | Jerry Jeudy | Cle vs Pit |
| 65 | Nick Westbrook | Ten @ Hou |
| 66 | Jaylen Waddle | Mia vs NE |
| 67 | Cade Otton | TB @ NYG |
| 68 | Javonte Williams | Den @ LV |
| 69 | Xavier Worthy | KC @ Car |
| 70 | Christian Watson | GB vs SF |
