All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Thu 12:03 PM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey (Q) | SF @ GB |
| 2 | De'Von Achane | Mia vs NE |
| 3 | Joe Mixon | Hou vs Ten |
| 4 | Saquon Barkley | Phi @ LAR |
| 5 | Derrick Henry | Bal @ LAC |
| 6 | Jahmyr Gibbs | Det vs Chi |
| 7 | Kenneth Walker III | Sea vs Ari |
| 8 | Kyren Williams | LAR vs Phi |
| 9 | Josh Jacobs (Q) | GB vs SF |
| 10 | Jonathan Taylor | Ind vs Det |
| 11 | James Conner | Ari @ Sea |
| 12 | David Montgomery | Det vs Chi |
| 13 | Aaron Jones (P) | Min @ Chi |
| 14 | J.K. Dobbins | LAC vs Bal |
| 15 | Brian Robinson | Wsh vs Dal |
| 16 | Rhamondre Stevenson | NE @ Mia |
| 17 | D'Andre Swift (Q) | Chi vs Min |
| 18 | Tyrone Tracy Jr. | NYG vs TB |
| 19 | Najee Harris | Pit @ Cle |
| 20 | Tony Pollard | Ten @ Hou |
| Rank | Player | Match |
| 21 | Chuba Hubbard | Car vs KC |
| 22 | Bucky Irving (P) | TB @ NYG |
| 23 | Rico Dowdle | Dal @ Wsh |
| 24 | Rachaad White | TB @ NYG |
| 25 | Nick Chubb | Cle vs Pit |
| 26 | Kareem Hunt (P) | KC @ Car |
| 27 | Austin Ekeler | Wsh vs Dal |
| 28 | Javonte Williams | Den @ LV |
| 29 | Jaylen Warren | Pit @ Cle |
| 30 | Isiah Pacheco (Q) | KC @ Car |
| 31 | Alexander Mattison (Q) | LV vs Den |
| 32 | Zach Charbonnet | Sea vs Ari |
| 33 | Jerome Ford | Cle vs Pit |
| 34 | Audric Estime | Den @ LV |
| 35 | Justice Hill | Bal @ LAC |
| 36 | Tyjae Spears (Q) | Ten @ Hou |
| 37 | Roschon Johnson | Chi vs Min |
| 38 | Jonathon Brooks (P) | Car vs KC |
| 39 | Cam Akers | Min @ Chi |
| 40 | Gus Edwards | LAC vs Bal |
