All position rankings are: QB | RB | WR | TE | FLEX | D
These rankings were updated as of Sat 12:19 PM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | Car vs Atl |
| 2 | Dalvin Cook | Min vs Den |
| 3 | Ezekiel Elliott | Dal @ Det |
| 4 | Josh Jacobs | Oak vs Cin |
| 5 | Alvin Kamara | NO @ TB |
| 6 | Leonard Fournette | Jax @ Ind |
| 7 | Le'Veon Bell (que) | NYJ @ Wsh |
| 8 | Tevin Coleman | SF vs Ari |
| 9 | Brian Hill | Atl @ Car |
| 10 | Melvin Gordon | LAC @ KC |
| 11 | Marlon Mack | Ind vs Jax |
| 12 | Todd Gurley | LAR vs Chi |
| 13 | Damien Williams | KC vs LAC |
| 14 | Mark Ingram | Bal vs Hou |
| 15 | Devin Singletary | Buf @ Mia |
| 16 | David Montgomery (que) | Chi @ LAR |
| 17 | Joe Mixon | Cin @ Oak |
| 18 | Austin Ekeler | LAC @ KC |
| 19 | James White | NE @ Phi |
| 20 | Kalen Ballage | Mia vs Buf |
| Rank | Player | Match |
| 21 | Phillip Lindsay | Den @ Min |
| 22 | Miles Sanders | Phi vs NE |
| 23 | Carlos Hyde | Hou @ Bal |
| 24 | Ronald Jones | TB vs NO |
| 25 | Kenyan Drake | Ari @ SF |
| 26 | Sony Michel | NE @ Phi |
| 27 | Royce Freeman (GTD) | Den @ Min |
| 28 | Derrius Guice | Wsh vs NYJ |
| 29 | Latavius Murray | NO @ TB |
| 30 | Duke Johnson | Hou @ Bal |
| 31 | Tarik Cohen | Chi @ LAR |
| 32 | David Johnson | Ari @ SF |
| 33 | Raheem Mostert (que) | SF vs Ari |
| 34 | Adrian Peterson | Wsh vs NYJ |
| 35 | J.D. McKissic | Det vs Dal |
| 36 | Ty Johnson (que) | Det vs Dal |
| 37 | Jordan Howard (que) | Phi vs NE |
| 38 | Nyheim Hines | Ind vs Jax |
| 39 | Frank Gore | Buf @ Mia |
| 40 | Peyton Barber | TB vs NO |
