All position rankings are: QB | RB | WR | TE | FLEX | D
These rankings were updated as of Sat 12:19 PM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | Car vs Atl |
| 2 | Dalvin Cook | Min vs Den |
| 3 | Michael Thomas | NO @ TB |
| 4 | Ezekiel Elliott | Dal @ Det |
| 5 | Josh Jacobs | Oak vs Cin |
| 6 | Alvin Kamara | NO @ TB |
| 7 | Leonard Fournette | Jax @ Ind |
| 8 | DeAndre Hopkins | Hou @ Bal |
| 9 | Tyreek Hill | KC vs LAC |
| 10 | Julio Jones | Atl @ Car |
| 11 | Le'Veon Bell (que) | NYJ @ Wsh |
| 12 | Mike Evans | TB vs NO |
| 13 | Tevin Coleman | SF vs Ari |
| 14 | Amari Cooper | Dal @ Det |
| 15 | Chris Godwin | TB vs NO |
| 16 | Cooper Kupp | LAR vs Chi |
| 17 | Brian Hill | Atl @ Car |
| 18 | Julian Edelman (GTD) | NE @ Phi |
| 19 | Keenan Allen | LAC @ KC |
| 20 | Melvin Gordon | LAC @ KC |
| 21 | Travis Kelce | KC vs LAC |
| 22 | Marlon Mack | Ind vs Jax |
| 23 | Todd Gurley | LAR vs Chi |
| 24 | Stefon Diggs | Min vs Den |
| 25 | Damien Williams | KC vs LAC |
| 26 | D.J. Moore | Car vs Atl |
| 27 | Mark Ingram | Bal vs Hou |
| 28 | Devin Singletary | Buf @ Mia |
| 29 | David Montgomery (que) | Chi @ LAR |
| 30 | Joe Mixon | Cin @ Oak |
| 31 | Courtland Sutton | Den @ Min |
| 32 | Allen Robinson | Chi @ LAR |
| 33 | Tyler Boyd | Cin @ Oak |
| 34 | Kenny Golladay | Det vs Dal |
| 35 | Hunter Henry | LAC @ KC |
| Rank | Player | Match |
| 36 | D.J. Chark | Jax @ Ind |
| 37 | Christian Kirk | Ari @ SF |
| 38 | Calvin Ridley | Atl @ Car |
| 39 | Mark Andrews | Bal vs Hou |
| 40 | John Brown | Buf @ Mia |
| 41 | Austin Ekeler | LAC @ KC |
| 42 | Darren Waller | Oak vs Cin |
| 43 | Tyrell Williams | Oak vs Cin |
| 44 | Robert Woods | LAR vs Chi |
| 45 | Terry McLaurin | Wsh vs NYJ |
| 46 | James White | NE @ Phi |
| 47 | Michael Gallup | Dal @ Det |
| 48 | Curtis Samuel | Car vs Atl |
| 49 | Emmanuel Sanders (que) | SF vs Ari |
| 50 | Zach Ertz | Phi vs NE |
| 51 | Sammy Watkins | KC vs LAC |
| 52 | Kalen Ballage | Mia vs Buf |
| 53 | Phillip Lindsay | Den @ Min |
| 54 | Mohamed Sanu | NE @ Phi |
| 55 | Miles Sanders | Phi vs NE |
| 56 | Jamison Crowder | NYJ @ Wsh |
| 57 | DeVante Parker | Mia vs Buf |
| 58 | Carlos Hyde | Hou @ Bal |
| 59 | Ronald Jones | TB vs NO |
| 60 | Kenyan Drake | Ari @ SF |
| 61 | Marquise Brown (que) | Bal vs Hou |
| 62 | Sony Michel | NE @ Phi |
| 63 | Mike Williams | LAC @ KC |
| 64 | Dede Westbrook | Jax @ Ind |
| 65 | Marvin Jones | Det vs Dal |
| 66 | Deebo Samuel | SF vs Ari |
| 67 | Royce Freeman (GTD) | Den @ Min |
| 68 | Derrius Guice | Wsh vs NYJ |
| 69 | Zach Pascal | Ind vs Jax |
| 70 | Latavius Murray | NO @ TB |
