All position rankings are: QB | RB | WR | TE | FLEX | D
These rankings were updated as of Sat 9:30 AM ET.
| Rank | Player | Match |
| 1 | Lamar Jackson (que) | Bal @ Cin |
| 2 | Patrick Mahomes | KC @ Ten |
| 3 | Drew Brees | NO vs Atl |
| 4 | Jameis Winston | TB vs Ari |
| 5 | Russell Wilson | Sea @ SF |
| 6 | Aaron Rodgers | GB vs Car |
| 7 | Kyler Murray | Ari @ TB |
| 8 | Dak Prescott | Dal vs Min |
| 9 | Matt Ryan | Atl @ NO |
| 10 | Jacoby Brissett (que) | Ind vs Mia |
| 11 | Josh Allen | Buf @ Cle |
| 12 | Jimmy Garoppolo | SF vs Sea |
| 13 | Jared Goff | LAR @ Pit |
| 14 | Daniel Jones | NYG @ NYJ |
| 15 | Kirk Cousins | Min @ Dal |
| 16 | Matthew Stafford (que) | Det @ Chi |
| 17 | Ryan Tannehill | Ten vs KC |
| 18 | Sam Darnold | NYJ vs NYG |
| 19 | Mitchell Trubisky | Chi vs Det |
| 20 | Baker Mayfield | Cle vs Buf |
| 21 | Kyle Allen | Car @ GB |
| 22 | Ryan Fitzpatrick | Mia @ Ind |
| 23 | Mason Rudolph | Pit vs LAR |
| 24 | Ryan Finley | Cin vs Bal |
| 25 | Andy Dalton | Cin vs Bal |
