All position rankings are: QB | RB | WR | TE | FLEX | D
These rankings were updated as of Sat 9:30 AM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | Car @ GB |
| 2 | Saquon Barkley | NYG @ NYJ |
| 3 | Alvin Kamara | NO vs Atl |
| 4 | Dalvin Cook | Min @ Dal |
| 5 | Ezekiel Elliott | Dal vs Min |
| 6 | Le'Veon Bell (que) | NYJ vs NYG |
| 7 | Nick Chubb | Cle vs Buf |
| 8 | Aaron Jones | GB vs Car |
| 9 | Marlon Mack | Ind vs Mia |
| 10 | Chris Carson | Sea @ SF |
| 11 | Jaylen Samuels | Pit vs LAR |
| 12 | Derrick Henry | Ten vs KC |
| 13 | David Johnson | Ari @ TB |
| 14 | Mark Ingram | Bal @ Cin |
| 15 | Todd Gurley | LAR @ Pit |
| 16 | David Montgomery | Chi vs Det |
| 17 | Tevin Coleman | SF vs Sea |
| 18 | Devonta Freeman | Atl @ NO |
| 19 | Ronald Jones | TB vs Ari |
| 20 | Devin Singletary | Buf @ Cle |
| Rank | Player | Match |
| 21 | Damien Williams | KC @ Ten |
| 22 | Joe Mixon | Cin vs Bal |
| 23 | Matt Breida (que) | SF vs Sea |
| 24 | Jamaal Williams | GB vs Car |
| 25 | Ty Johnson | Det @ Chi |
| 26 | Latavius Murray | NO vs Atl |
| 27 | Kalen Ballage | Mia @ Ind |
| 28 | Tarik Cohen | Chi vs Det |
| 29 | Kenyan Drake | Ari @ TB |
| 30 | J.D. McKissic | Det @ Chi |
| 31 | Nyheim Hines | Ind vs Mia |
| 32 | Trey Edmunds | Pit vs LAR |
| 33 | Frank Gore | Buf @ Cle |
| 34 | Peyton Barber | TB vs Ari |
| 35 | Dion Lewis | Ten vs KC |
| 36 | Giovani Bernard | Cin vs Bal |
| 37 | LeSean McCoy | KC @ Ten |
| 38 | Kareem Hunt | Cle vs Buf |
| 39 | Brian Hill | Atl @ NO |
| 40 | Gus Edwards | Bal @ Cin |
