All position rankings are: QB | RB | WR | TE | FLEX | D
These rankings were updated as of Sat 9:30 AM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | Car @ GB |
| 2 | Saquon Barkley | NYG @ NYJ |
| 3 | Michael Thomas | NO vs Atl |
| 4 | Alvin Kamara | NO vs Atl |
| 5 | Dalvin Cook | Min @ Dal |
| 6 | Ezekiel Elliott | Dal vs Min |
| 7 | Le'Veon Bell (que) | NYJ vs NYG |
| 8 | Mike Evans | TB vs Ari |
| 9 | Nick Chubb | Cle vs Buf |
| 10 | Tyreek Hill | KC @ Ten |
| 11 | Julio Jones | Atl @ NO |
| 12 | Chris Godwin | TB vs Ari |
| 13 | Aaron Jones | GB vs Car |
| 14 | Marlon Mack | Ind vs Mia |
| 15 | Cooper Kupp | LAR @ Pit |
| 16 | Davante Adams | GB vs Car |
| 17 | Chris Carson | Sea @ SF |
| 18 | Stefon Diggs | Min @ Dal |
| 19 | Jaylen Samuels | Pit vs LAR |
| 20 | Tyler Lockett (que) | Sea @ SF |
| 21 | Derrick Henry | Ten vs KC |
| 22 | David Johnson | Ari @ TB |
| 23 | Mark Ingram | Bal @ Cin |
| 24 | Amari Cooper (que) | Dal vs Min |
| 25 | Travis Kelce | KC @ Ten |
| 26 | Todd Gurley | LAR @ Pit |
| 27 | Kenny Golladay | Det @ Chi |
| 28 | David Montgomery | Chi vs Det |
| 29 | Odell Beckham | Cle vs Buf |
| 30 | Tevin Coleman | SF vs Sea |
| 31 | Devonta Freeman | Atl @ NO |
| 32 | Allen Robinson | Chi vs Det |
| 33 | Christian Kirk | Ari @ TB |
| 34 | Ronald Jones | TB vs Ari |
| 35 | Robert Woods | LAR @ Pit |
| Rank | Player | Match |
| 36 | Devin Singletary | Buf @ Cle |
| 37 | George Kittle (que) | SF vs Sea |
| 38 | Damien Williams | KC @ Ten |
| 39 | Mark Andrews | Bal @ Cin |
| 40 | Emmanuel Sanders | SF vs Sea |
| 41 | JuJu Smith-Schuster (que) | Pit vs LAR |
| 42 | Austin Hooper | Atl @ NO |
| 43 | Tyler Boyd | Cin vs Bal |
| 44 | Golden Tate | NYG @ NYJ |
| 45 | John Brown | Buf @ Cle |
| 46 | D.J. Moore | Car @ GB |
| 47 | Calvin Ridley | Atl @ NO |
| 48 | Curtis Samuel | Car @ GB |
| 49 | Sammy Watkins | KC @ Ten |
| 50 | Jamison Crowder | NYJ vs NYG |
| 51 | Marvin Jones | Det @ Chi |
| 52 | Joe Mixon | Cin vs Bal |
| 53 | D.K. Metcalf | Sea @ SF |
| 54 | Michael Gallup | Dal vs Min |
| 55 | A.J. Brown | Ten vs KC |
| 56 | Zach Pascal | Ind vs Mia |
| 57 | DeVante Parker | Mia @ Ind |
| 58 | Jarvis Landry | Cle vs Buf |
| 59 | Larry Fitzgerald | Ari @ TB |
| 60 | Matt Breida (que) | SF vs Sea |
| 61 | Jamaal Williams | GB vs Car |
| 62 | Marquise Brown (que) | Bal @ Cin |
| 63 | Robby Anderson | NYJ vs NYG |
| 64 | Ty Johnson | Det @ Chi |
| 65 | Latavius Murray | NO vs Atl |
| 66 | Ted Ginn Jr. | NO vs Atl |
| 67 | Adam Humphries | Ten vs KC |
| 68 | Cole Beasley | Buf @ Cle |
| 69 | Danny Amendola | Det @ Chi |
| 70 | Darius Slayton | NYG @ NYJ |
