All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sat 12:54 PM ET.
| Rank | Player | Match |
| 1 | Puka Nacua | LAR vs Ari |
| 2 | CeeDee Lamb | Dal @ GB |
| 3 | Christian Watson | GB vs Dal |
| 4 | Drake London | Atl vs Chi |
| 5 | Nico Collins | Hou @ Jax |
| 6 | Mike Evans (Q) | SF vs Wsh |
| 7 | Chris Olave (Q) | NO @ NYG |
| 8 | Davante Adams | LAR vs Ari |
| 9 | Zay Flowers | Bal @ Cle |
| 10 | A.J. Brown (IR) | NE vs NYJ |
| 11 | George Pickens | Dal @ GB |
| 12 | Tetairoa McMillan | Car @ Phi |
| 13 | Garrett Wilson | NYJ @ NE |
| 14 | Parker Washington | Jax vs Hou |
| 15 | Malik Nabers | NYG vs NO |
| 16 | Matthew Golden | GB vs Dal |
| 17 | D.K. Metcalf (Q) | Pit @ TB |
| 18 | Jalen Coker | Car @ Phi |
| 19 | Xavier Worthy | KC vs LAC |
| 20 | Luther Burden III | Chi @ Atl |
| 21 | Josh Downs | Ind vs Ten |
| 22 | Terry McLaurin (Q) | Wsh @ SF |
| 23 | DeVonta Smith | Phi vs Car |
| 24 | Michael Wilson | Ari @ LAR |
| 25 | Emeka Egbuka | TB vs Pit |
| Rank | Player | Match |
| 26 | D.J. Moore (Q) | Buf @ LV |
| 27 | Denzel Boston | Cle vs Bal |
| 28 | Carnell Tate | Ten @ Ind |
| 29 | Keenan Allen | Ind vs Ten |
| 30 | Devaughn Vele | NO @ NYG |
| 31 | Rome Odunze | Chi @ Atl |
| 32 | Romeo Doubs | NE vs NYJ |
| 33 | Khalil Shakir | Buf @ LV |
| 34 | Stefon Diggs (Q) | Wsh @ SF |
| 35 | Tre Tucker | LV vs Buf |
| 36 | Germie Bernard | Pit @ TB |
| 37 | Keon Coleman | Buf @ LV |
| 38 | Wan'Dale Robinson | Ten @ Ind |
| 39 | Jakobi Meyers | Jax vs Hou |
| 40 | Chris Godwin | TB vs Pit |
| 41 | KC Concepcion Jr. | Cle vs Bal |
| 42 | Kalif Raymond | Chi @ Atl |
| 43 | Ladd McConkey | LAC @ KC |
| 44 | Ryan Flournoy | Dal @ GB |
| 45 | Kendrick Bourne | Ari @ LAR |
| 46 | Demario Douglas | NE vs NYJ |
| 47 | Rashod Bateman | Bal @ Cle |
| 48 | Rashee Rice (Out) | KC vs LAC |
| 49 | Dontayvion Wicks | Phi vs Car |
| 50 | Brandin Cooks | SF vs Wsh |
