All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Thu 11:17 AM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | SF @ Ind |
| 2 | Bijan Robinson | Atl @ Ari |
| 3 | De'Von Achane | Mia vs Cin |
| 4 | Jahmyr Gibbs | Det vs Pit |
| 5 | Jonathan Taylor | Ind vs SF |
| 6 | Saquon Barkley | Phi @ Wsh |
| 7 | Josh Jacobs | GB @ Chi |
| 8 | Chase Brown | Cin @ Mia |
| 9 | James Cook | Buf @ Cle |
| 10 | Derrick Henry | Bal vs NE |
| 11 | Bucky Irving | TB @ Car |
| 12 | Javonte Williams | Dal vs LAC |
| 13 | Breece Hall | NYJ @ NO |
| 14 | Travis Etienne | Jax @ Den |
| 15 | Rico Dowdle | Car vs TB |
| 16 | Quinshon Judkins | Cle vs Buf |
| 17 | TreVeyon Henderson | NE @ Bal |
| 18 | Kyren Williams | LAR @ Sea |
| 19 | Ashton Jeanty | LV @ Hou |
| 20 | Omarion Hampton | LAC @ Dal |
| Rank | Player | Match |
| 21 | Jaylen Warren | Pit @ Det |
| 22 | RJ Harvey | Den vs Jax |
| 23 | D'Andre Swift (Q) | Chi vs GB |
| 24 | Tyrone Tracy Jr. | NYG vs Min |
| 25 | Kenneth Gainwell | Pit @ Det |
| 26 | Aaron Jones | Min @ NYG |
| 27 | Kenneth Walker III | Sea vs LAR |
| 28 | Michael Carter | Ari vs Atl |
| 29 | David Montgomery | Det vs Pit |
| 30 | Tony Pollard | Ten vs KC |
| 31 | Kimani Vidal | LAC @ Dal |
| 32 | Jacory Croskey-Merritt | Wsh vs Phi |
| 33 | Kareem Hunt | KC @ Ten |
| 34 | Chuba Hubbard | Car vs TB |
| 35 | Kyle Monangai | Chi vs GB |
| 36 | Jordan Mason | Min @ NYG |
| 37 | Zach Charbonnet | Sea vs LAR |
| 38 | Blake Corum | LAR @ Sea |
| 39 | Woody Marks | Hou vs LV |
| 40 | Rhamondre Stevenson | NE @ Bal |
