All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Thu 11:58 AM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | SF vs Car |
| 2 | Bijan Robinson | Atl @ NO |
| 3 | Jahmyr Gibbs | Det vs NYG |
| 4 | Jonathan Taylor | Ind @ KC |
| 5 | James Cook | Buf @ Hou |
| 6 | Saquon Barkley | Phi @ Dal |
| 7 | Derrick Henry | Bal vs NYJ |
| 8 | TreVeyon Henderson | NE @ Cin |
| 9 | Chase Brown | Cin vs NE |
| 10 | Rico Dowdle | Car @ SF |
| 11 | Breece Hall | NYJ @ Bal |
| 12 | Kyren Williams | LAR vs TB |
| 13 | Travis Etienne (Q) | Jax @ Ari |
| 14 | Ashton Jeanty | LV vs Cle |
| 15 | Javonte Williams | Dal vs Phi |
| 16 | Quinshon Judkins | Cle @ LV |
| 17 | Kenneth Walker III | Sea @ Ten |
| 18 | Emanuel Wilson | GB vs Min |
| 19 | D'Andre Swift (Q) | Chi vs Pit |
| 20 | Alvin Kamara (Q) | NO vs Atl |
| Rank | Player | Match |
| 21 | Woody Marks | Hou vs Buf |
| 22 | David Montgomery | Det vs NYG |
| 23 | Tyrone Tracy Jr. | NYG @ Det |
| 24 | Jaylen Warren (Q) | Pit @ Chi |
| 25 | Kenneth Gainwell | Pit @ Chi |
| 26 | Zach Charbonnet | Sea @ Ten |
| 27 | Rachaad White | TB @ LAR |
| 28 | Aaron Jones | Min @ GB |
| 29 | Kareem Hunt | KC vs Ind |
| 30 | Bam Knight (Q) | Ari vs Jax |
| 31 | Tyjae Spears | Ten vs Sea |
| 32 | Tony Pollard | Ten vs Sea |
| 33 | Bhayshul Tuten (Q) | Jax @ Ari |
| 34 | Michael Carter | Ari vs Jax |
| 35 | Devin Singletary | NYG @ Det |
| 36 | Isiah Pacheco | KC vs Ind |
| 37 | Kyle Monangai | Chi vs Pit |
| 38 | Tyler Allgeier | Atl @ NO |
| 39 | Bucky Irving (Q) | TB @ LAR |
| 40 | Jordan Mason | Min @ GB |
