All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sat 12:36 PM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | SF vs LAR |
| 2 | James Cook | Buf @ Mia |
| 3 | De'Von Achane | Mia vs Buf |
| 4 | Jahmyr Gibbs | Det @ Wsh |
| 5 | Puka Nacua | LAR @ SF |
| 6 | Amon-Ra St. Brown | Det @ Wsh |
| 7 | Josh Jacobs | GB vs Phi |
| 8 | Jaxon Smith-Njigba | Sea vs Ari |
| 9 | Rico Dowdle | Car vs NO |
| 10 | Saquon Barkley | Phi @ GB |
| 11 | Emeka Egbuka | TB vs NE |
| 12 | Kyren Williams | LAR @ SF |
| 13 | Justin Jefferson | Min vs Bal |
| 14 | Derrick Henry | Bal @ Min |
| 15 | Davante Adams | LAR @ SF |
| 16 | Omarion Hampton (IR) | LAC vs Pit |
| 17 | Quinshon Judkins | Cle @ NYJ |
| 18 | TreVeyon Henderson | NE @ TB |
| 19 | Breece Hall | NYJ vs Cle |
| 20 | Travis Etienne | Jax @ Hou |
| 21 | Zay Flowers | Bal @ Min |
| 22 | D'Andre Swift (Q) | Chi vs NYG |
| 23 | Alvin Kamara (Q) | NO @ Car |
| 24 | Jaylen Warren | Pit @ LAC |
| 25 | Kenneth Walker III | Sea vs Ari |
| 26 | Rachaad White | TB vs NE |
| 27 | Jaylen Waddle | Mia vs Buf |
| 28 | Ladd McConkey | LAC vs Pit |
| 29 | A.J. Brown | Phi @ GB |
| 30 | Nico Collins | Hou vs Jax |
| 31 | Stefon Diggs | NE @ TB |
| 32 | Deebo Samuel | Wsh vs Det |
| 33 | Rome Odunze | Chi vs NYG |
| 34 | Chris Olave | NO @ Car |
| 35 | Trey McBride | Ari @ Sea |
| Rank | Player | Match |
| 36 | Garrett Wilson (Q) | NYJ vs Cle |
| 37 | D.K. Metcalf | Pit @ LAC |
| 38 | Sam LaPorta | Det @ Wsh |
| 39 | Tetairoa McMillan (Q) | Car vs NO |
| 40 | Khalil Shakir | Buf @ Mia |
| 41 | DeVonta Smith | Phi @ GB |
| 42 | Romeo Doubs | GB vs Phi |
| 43 | Wan'Dale Robinson | NYG @ Chi |
| 44 | David Montgomery | Det @ Wsh |
| 45 | Marvin Harrison Jr. | Ari @ Sea |
| 46 | Keenan Allen | LAC vs Pit |
| 47 | Jameson Williams | Det @ Wsh |
| 48 | Oronde Gadsden | LAC vs Pit |
| 49 | Quentin Johnston | LAC vs Pit |
| 50 | Woody Marks | Hou vs Jax |
| 51 | Jordan Addison | Min vs Bal |
| 52 | Dalton Kincaid | Buf @ Mia |
| 53 | Aaron Jones (Q) | Min vs Bal |
| 54 | Jacory Croskey-Merritt | Wsh vs Det |
| 55 | Tyrone Tracy Jr. | NYG @ Chi |
| 56 | George Kittle | SF vs LAR |
| 57 | Hunter Henry | NE @ TB |
| 58 | Parker Washington | Jax @ Hou |
| 59 | DJ Moore | Chi vs NYG |
| 60 | David Njoku | Cle @ NYJ |
| 61 | Zach Charbonnet | Sea vs Ari |
| 62 | Rashid Shaheed | Sea vs Ari |
| 63 | Harold Fannin Jr. (Q) | Cle @ NYJ |
| 64 | Kyle Monangai | Chi vs NYG |
| 65 | Dallas Goedert | Phi @ GB |
| 66 | Jauan Jennings | SF vs LAR |
| 67 | Zach Ertz | Wsh vs Det |
| 68 | Cade Otton | TB vs NE |
| 69 | Theo Johnson | NYG @ Chi |
| 70 | Jakobi Meyers | LV @ Den |
