All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sat 12:35 PM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | SF vs LAR |
| 2 | James Cook | Buf @ Mia |
| 3 | De'Von Achane | Mia vs Buf |
| 4 | Jahmyr Gibbs | Det @ Wsh |
| 5 | Josh Jacobs | GB vs Phi |
| 6 | Rico Dowdle | Car vs NO |
| 7 | Saquon Barkley | Phi @ GB |
| 8 | Kyren Williams | LAR @ SF |
| 9 | Derrick Henry | Bal @ Min |
| 10 | Omarion Hampton (IR) | LAC vs Pit |
| 11 | Quinshon Judkins | Cle @ NYJ |
| 12 | TreVeyon Henderson | NE @ TB |
| 13 | Breece Hall | NYJ vs Cle |
| 14 | Travis Etienne | Jax @ Hou |
| 15 | D'Andre Swift (Q) | Chi vs NYG |
| 16 | Alvin Kamara (Q) | NO @ Car |
| 17 | Jaylen Warren | Pit @ LAC |
| 18 | Kenneth Walker III | Sea vs Ari |
| 19 | Rachaad White | TB vs NE |
| 20 | David Montgomery | Det @ Wsh |
| Rank | Player | Match |
| 21 | Woody Marks | Hou vs Jax |
| 22 | Aaron Jones (Q) | Min vs Bal |
| 23 | Jacory Croskey-Merritt | Wsh vs Det |
| 24 | Tyrone Tracy Jr. | NYG @ Chi |
| 25 | Zach Charbonnet | Sea vs Ari |
| 26 | Kyle Monangai | Chi vs NYG |
| 27 | Jordan Mason | Min vs Bal |
| 28 | Kenneth Gainwell | Pit @ LAC |
| 29 | Emari Demercado | Ari @ Sea |
| 30 | Kimani Vidal | LAC vs Pit |
| 31 | Nick Chubb | Hou vs Jax |
| 32 | Bam Knight | Ari @ Sea |
| 33 | Terrell Jennings | NE @ TB |
| 34 | Devin Singletary | NYG @ Chi |
| 35 | Blake Corum | LAR @ SF |
| 36 | Chuba Hubbard | Car vs NO |
| 37 | Sean Tucker | TB vs NE |
| 38 | Ollie Gordon (Q) | Mia vs Buf |
| 39 | Bhayshul Tuten | Jax @ Hou |
| 40 | Emanuel Wilson | GB vs Phi |
