All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Thu 11:51 AM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | SF vs LAR |
| 2 | Jonathan Taylor | Ind vs Atl |
| 3 | Bijan Robinson | Atl @ Ind |
| 4 | De'Von Achane | Mia vs Buf |
| 5 | Jahmyr Gibbs | Det @ Wsh |
| 6 | James Cook | Buf @ Mia |
| 7 | Josh Jacobs | GB vs Phi |
| 8 | Rico Dowdle (Q) | Car vs NO |
| 9 | Kyren Williams | LAR @ SF |
| 10 | Saquon Barkley | Phi @ GB |
| 11 | Omarion Hampton | LAC vs Pit |
| 12 | Bucky Irving | TB vs NE |
| 13 | Derrick Henry | Bal @ Min |
| 14 | Breece Hall | NYJ vs Cle |
| 15 | Ashton Jeanty | LV @ Den |
| 16 | Quinshon Judkins | Cle @ NYJ |
| 17 | Travis Etienne | Jax @ Hou |
| 18 | Alvin Kamara (Q) | NO @ Car |
| 19 | J.K. Dobbins | Den vs LV |
| 20 | Jaylen Warren | Pit @ LAC |
| Rank | Player | Match |
| 21 | Kenneth Walker III | Sea vs Ari |
| 22 | TreVeyon Henderson | NE @ TB |
| 23 | Kyle Monangai | Chi vs NYG |
| 24 | David Montgomery | Det @ Wsh |
| 25 | D'Andre Swift | Chi vs NYG |
| 26 | Woody Marks | Hou vs Jax |
| 27 | Aaron Jones | Min vs Bal |
| 28 | Rachaad White | TB vs NE |
| 29 | Jacory Croskey-Merritt (Q) | Wsh vs Det |
| 30 | Tyrone Tracy Jr. | NYG @ Chi |
| 31 | RJ Harvey | Den vs LV |
| 32 | Zach Charbonnet | Sea vs Ari |
| 33 | Jordan Mason | Min vs Bal |
| 34 | Kenneth Gainwell | Pit @ LAC |
| 35 | Kimani Vidal | LAC vs Pit |
| 36 | Nick Chubb | Hou vs Jax |
| 37 | Emari Demercado | Ari @ Sea |
| 38 | Devin Singletary | NYG @ Chi |
| 39 | Blake Corum | LAR @ SF |
| 40 | Bam Knight | Ari @ Sea |
