All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sat 1:52 PM ET.
| Rank | Player | Match |
| 1 | Jonathan Taylor | Ind vs LV |
| 2 | De'Von Achane | Mia @ Car |
| 3 | Jahmyr Gibbs | Det @ Cin |
| 4 | Omarion Hampton | LAC vs Wsh |
| 5 | Amon-Ra St. Brown | Det @ Cin |
| 6 | James Cook | Buf vs NE |
| 7 | Saquon Barkley | Phi vs Den |
| 8 | Cam Skattebo | NYG vs Phi |
| 9 | Derrick Henry | Bal vs Hou |
| 10 | Breece Hall | NYJ vs Dal |
| 11 | George Pickens | Dal @ NYJ |
| 12 | Ashton Jeanty | LV @ Ind |
| 13 | Javonte Williams | Dal @ NYJ |
| 14 | Ja'Marr Chase | Cin vs Det |
| 15 | Jaxon Smith-Njigba | Sea vs TB |
| 16 | Alvin Kamara | NO vs NYG |
| 17 | Nico Collins | Hou @ Bal |
| 18 | Chase Brown | Cin vs Det |
| 19 | Travis Etienne | Jax vs KC |
| 20 | Quentin Johnston | LAC vs Wsh |
| 21 | Garrett Wilson | NYJ vs Dal |
| 22 | Emeka Egbuka | TB @ Sea |
| 23 | Woody Marks | Hou @ Bal |
| 24 | Rico Dowdle | Car vs Mia |
| 25 | Trey McBride | Ari vs Ten |
| 26 | Keenan Allen | LAC vs Wsh |
| 27 | Jaylen Waddle | Mia @ Car |
| 28 | Rachaad White | TB @ Sea |
| 29 | Ladd McConkey | LAC vs Wsh |
| 30 | Jakobi Meyers | LV @ Ind |
| 31 | A.J. Brown | Phi vs Den |
| 32 | David Montgomery | Det @ Cin |
| 33 | Tetairoa McMillan | Car vs Mia |
| 34 | Michael Pittman Jr. | Ind vs LV |
| 35 | Kenneth Walker III | Sea vs TB |
| Rank | Player | Match |
| 36 | Brock Bowers (Q) | LV @ Ind |
| 37 | Marvin Harrison Jr. | Ari vs Ten |
| 38 | Tyler Warren | Ind vs LV |
| 39 | Deebo Samuel | Wsh @ LAC |
| 40 | Courtland Sutton | Den @ Phi |
| 41 | Jameson Williams | Det @ Cin |
| 42 | Tony Pollard | Ten @ Ari |
| 43 | Chris Godwin | TB @ Sea |
| 44 | Brian Thomas Jr. | Jax vs KC |
| 45 | Jacory Croskey-Merritt | Wsh @ LAC |
| 46 | J.K. Dobbins | Den @ Phi |
| 47 | Xavier Worthy | KC @ Jax |
| 48 | Zay Flowers | Bal vs Hou |
| 49 | Jake Ferguson | Dal @ NYJ |
| 50 | Emari Demercado | Ari vs Ten |
| 51 | Tee Higgins | Cin vs Det |
| 52 | DeVonta Smith | Phi vs Den |
| 53 | Chris Olave | NO vs NYG |
| 54 | Sam LaPorta | Det @ Cin |
| 55 | Keon Coleman | Buf vs NE |
| 56 | Wan'Dale Robinson | NYG vs Phi |
| 57 | Khalil Shakir | Buf vs NE |
| 58 | Darren Waller | Mia @ Car |
| 59 | Travis Kelce | KC @ Jax |
| 60 | TreVeyon Henderson | NE @ Buf |
| 61 | Hunter Henry | NE @ Buf |
| 62 | Stefon Diggs | NE @ Buf |
| 63 | Calvin Ridley (Q) | Ten @ Ari |
| 64 | Cooper Kupp | Sea vs TB |
| 65 | Zach Charbonnet | Sea vs TB |
| 66 | Isiah Pacheco | KC @ Jax |
| 67 | Rhamondre Stevenson | NE @ Buf |
| 68 | Rashid Shaheed | NO vs NYG |
| 69 | Michael Carter | Ari vs Ten |
| 70 | Malik Washington | Mia @ Car |
