All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Thu 3:08 PM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | SF @ LAR |
| 2 | Jahmyr Gibbs | Det @ Cin |
| 3 | De'Von Achane | Mia @ Car |
| 4 | Jonathan Taylor | Ind vs LV |
| 5 | Puka Nacua | LAR vs SF |
| 6 | Amon-Ra St. Brown | Det @ Cin |
| 7 | Omarion Hampton | LAC vs Wsh |
| 8 | Saquon Barkley | Phi vs Den |
| 9 | James Cook | Buf vs NE |
| 10 | Cam Skattebo (P) | NYG vs Phi |
| 11 | Derrick Henry | Bal vs Hou |
| 12 | Ashton Jeanty | LV @ Ind |
| 13 | Ja'Marr Chase | Cin vs Det |
| 14 | Kyren Williams | LAR vs SF |
| 15 | Breece Hall | NYJ vs Dal |
| 16 | George Pickens | Dal @ NYJ |
| 17 | Garrett Wilson | NYJ vs Dal |
| 18 | Javonte Williams | Dal @ NYJ |
| 19 | Jaxon Smith-Njigba | Sea vs TB |
| 20 | Nico Collins (Q) | Hou @ Bal |
| 21 | Alvin Kamara | NO vs NYG |
| 22 | Quinshon Judkins | Cle vs Min |
| 23 | Chase Brown | Cin vs Det |
| 24 | Bucky Irving (Q) | TB @ Sea |
| 25 | Davante Adams | LAR vs SF |
| 26 | Chuba Hubbard (Q) | Car vs Mia |
| 27 | Jordan Mason | Min @ Cle |
| 28 | Quentin Johnston | LAC vs Wsh |
| 29 | Justin Jefferson | Min @ Cle |
| 30 | Travis Etienne | Jax vs KC |
| 31 | Trey McBride | Ari vs Ten |
| 32 | Michael Pittman Jr. | Ind vs LV |
| 33 | Keenan Allen | LAC vs Wsh |
| 34 | Jaylen Waddle | Mia @ Car |
| 35 | David Montgomery | Det @ Cin |
| Rank | Player | Match |
| 36 | Emeka Egbuka | TB @ Sea |
| 37 | Woody Marks | Hou @ Bal |
| 38 | Ladd McConkey | LAC vs Wsh |
| 39 | Tyler Warren | Ind vs LV |
| 40 | Marvin Harrison Jr. | Ari vs Ten |
| 41 | Jakobi Meyers | LV @ Ind |
| 42 | Brock Bowers (Q) | LV @ Ind |
| 43 | Tetairoa McMillan (P) | Car vs Mia |
| 44 | Jameson Williams | Det @ Cin |
| 45 | A.J. Brown | Phi vs Den |
| 46 | Kenneth Walker III | Sea vs TB |
| 47 | Tony Pollard | Ten @ Ari |
| 48 | Deebo Samuel (Q) | Wsh @ LAC |
| 49 | Xavier Worthy | KC @ Jax |
| 50 | Tee Higgins | Cin vs Det |
| 51 | Brian Thomas Jr. | Jax vs KC |
| 52 | Zay Flowers | Bal vs Hou |
| 53 | J.K. Dobbins | Den @ Phi |
| 54 | Courtland Sutton | Den @ Phi |
| 55 | Emari Demercado | Ari vs Ten |
| 56 | DeVonta Smith | Phi vs Den |
| 57 | Sam LaPorta | Det @ Cin |
| 58 | Jake Ferguson | Dal @ NYJ |
| 59 | Chris Godwin (P) | TB @ Sea |
| 60 | Darren Waller (Q) | Mia @ Car |
| 61 | Chris Olave | NO vs NYG |
| 62 | Jordan Addison | Min @ Cle |
| 63 | Khalil Shakir | Buf vs NE |
| 64 | Rashid Shaheed | NO vs NYG |
| 65 | Wan'Dale Robinson | NYG vs Phi |
| 66 | Travis Kelce | KC @ Jax |
| 67 | Zach Charbonnet | Sea vs TB |
| 68 | Jerry Jeudy | Cle vs Min |
| 69 | Keon Coleman | Buf vs NE |
| 70 | Hunter Henry | NE @ Buf |
