All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sat 1:52 PM ET.
| Rank | Player | Match |
| 1 | Jonathan Taylor | Ind vs LV |
| 2 | De'Von Achane | Mia @ Car |
| 3 | Jahmyr Gibbs | Det @ Cin |
| 4 | Omarion Hampton | LAC vs Wsh |
| 5 | James Cook | Buf vs NE |
| 6 | Saquon Barkley | Phi vs Den |
| 7 | Cam Skattebo | NYG vs Phi |
| 8 | Derrick Henry | Bal vs Hou |
| 9 | Breece Hall | NYJ vs Dal |
| 10 | Ashton Jeanty | LV @ Ind |
| 11 | Javonte Williams | Dal @ NYJ |
| 12 | Alvin Kamara | NO vs NYG |
| 13 | Chase Brown | Cin vs Det |
| 14 | Travis Etienne | Jax vs KC |
| 15 | Woody Marks | Hou @ Bal |
| 16 | Rico Dowdle | Car vs Mia |
| 17 | Rachaad White | TB @ Sea |
| 18 | David Montgomery | Det @ Cin |
| 19 | Kenneth Walker III | Sea vs TB |
| 20 | Tony Pollard | Ten @ Ari |
| Rank | Player | Match |
| 21 | Jacory Croskey-Merritt | Wsh @ LAC |
| 22 | J.K. Dobbins | Den @ Phi |
| 23 | Emari Demercado | Ari vs Ten |
| 24 | TreVeyon Henderson | NE @ Buf |
| 25 | Zach Charbonnet | Sea vs TB |
| 26 | Isiah Pacheco | KC @ Jax |
| 27 | Rhamondre Stevenson | NE @ Buf |
| 28 | Michael Carter | Ari vs Ten |
| 29 | RJ Harvey | Den @ Phi |
| 30 | Kareem Hunt | KC @ Jax |
| 31 | Trevor Etienne | Car vs Mia |
| 32 | Sean Tucker | TB @ Sea |
| 33 | Ollie Gordon | Mia @ Car |
| 34 | Nick Chubb | Hou @ Bal |
| 35 | Bhayshul Tuten (Q) | Jax vs KC |
| 36 | Kendre Miller | NO vs NYG |
| 37 | Isaiah Davis | NYJ vs Dal |
| 38 | Jeremy McNichols | Wsh @ LAC |
| 39 | Justice Hill | Bal vs Hou |
| 40 | Chris Rodriguez Jr. | Wsh @ LAC |
