All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Thu 3:07 PM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | SF @ LAR |
| 2 | Jahmyr Gibbs | Det @ Cin |
| 3 | De'Von Achane | Mia @ Car |
| 4 | Jonathan Taylor | Ind vs LV |
| 5 | Omarion Hampton | LAC vs Wsh |
| 6 | Saquon Barkley | Phi vs Den |
| 7 | James Cook | Buf vs NE |
| 8 | Cam Skattebo (P) | NYG vs Phi |
| 9 | Derrick Henry | Bal vs Hou |
| 10 | Ashton Jeanty | LV @ Ind |
| 11 | Kyren Williams | LAR vs SF |
| 12 | Breece Hall | NYJ vs Dal |
| 13 | Javonte Williams | Dal @ NYJ |
| 14 | Alvin Kamara | NO vs NYG |
| 15 | Quinshon Judkins | Cle vs Min |
| 16 | Chase Brown | Cin vs Det |
| 17 | Bucky Irving (Q) | TB @ Sea |
| 18 | Chuba Hubbard (Q) | Car vs Mia |
| 19 | Jordan Mason | Min @ Cle |
| 20 | Travis Etienne | Jax vs KC |
| Rank | Player | Match |
| 21 | David Montgomery | Det @ Cin |
| 22 | Woody Marks | Hou @ Bal |
| 23 | Kenneth Walker III | Sea vs TB |
| 24 | Tony Pollard | Ten @ Ari |
| 25 | J.K. Dobbins | Den @ Phi |
| 26 | Emari Demercado | Ari vs Ten |
| 27 | Zach Charbonnet | Sea vs TB |
| 28 | TreVeyon Henderson | NE @ Buf |
| 29 | Rachaad White | TB @ Sea |
| 30 | Michael Carter | Ari vs Ten |
| 31 | RJ Harvey | Den @ Phi |
| 32 | Rhamondre Stevenson | NE @ Buf |
| 33 | Isiah Pacheco | KC @ Jax |
| 34 | Jacory Croskey-Merritt | Wsh @ LAC |
| 35 | Kareem Hunt | KC @ Jax |
| 36 | Nick Chubb | Hou @ Bal |
| 37 | Bhayshul Tuten | Jax vs KC |
| 38 | Ollie Gordon | Mia @ Car |
| 39 | Rico Dowdle | Car vs Mia |
| 40 | Kendre Miller | NO vs NYG |
