All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Wed 12:11 PM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | SF @ Buf |
| 2 | Alvin Kamara | NO vs LAR |
| 3 | Joe Mixon | Hou @ Jax |
| 4 | Bijan Robinson | Atl vs LAC |
| 5 | Ja'Marr Chase | Cin vs Pit |
| 6 | Jahmyr Gibbs | Det vs Chi |
| 7 | Saquon Barkley | Phi @ Bal |
| 8 | Chase Brown | Cin vs Pit |
| 9 | Kyren Williams | LAR @ NO |
| 10 | Breece Hall | NYJ vs Sea |
| 11 | Derrick Henry | Bal vs Phi |
| 12 | De'Von Achane | Mia @ GB |
| 13 | Puka Nacua | LAR @ NO |
| 14 | Justin Jefferson | Min vs Ari |
| 15 | Nico Collins | Hou @ Jax |
| 16 | Amon-Ra St. Brown (Q) | Det vs Chi |
| 17 | Josh Jacobs | GB vs Mia |
| 18 | A.J. Brown | Phi @ Bal |
| 19 | Tee Higgins | Cin vs Pit |
| 20 | Cooper Kupp | LAR @ NO |
| 21 | CeeDee Lamb (Q) | Dal vs NYG |
| 22 | Kenneth Walker III | Sea @ NYJ |
| 23 | Aaron Jones | Min vs Ari |
| 24 | Jonathan Taylor | Ind @ NE |
| 25 | George Pickens | Pit @ Cin |
| 26 | Chuba Hubbard | Car vs TB |
| 27 | Mike Evans | TB @ Car |
| 28 | Drake London | Atl vs LAC |
| 29 | Ladd McConkey | LAC @ Atl |
| 30 | Travis Kelce | KC vs LV |
| 31 | James Cook | Buf vs SF |
| 32 | James Conner | Ari @ Min |
| 33 | Tyrone Tracy Jr. | NYG @ Dal |
| 34 | Davante Adams | NYJ vs Sea |
| 35 | Tyreek Hill (Q) | Mia @ GB |
| Rank | Player | Match |
| 36 | Tony Pollard | Ten @ Wsh |
| 37 | Terry McLaurin | Wsh vs Ten |
| 38 | Garrett Wilson | NYJ vs Sea |
| 39 | Malik Nabers | NYG @ Dal |
| 40 | Courtland Sutton | Den vs Cle |
| 41 | George Kittle | SF @ Buf |
| 42 | Rhamondre Stevenson | NE vs Ind |
| 43 | Jaxon Smith-Njigba | Sea @ NYJ |
| 44 | Zay Flowers | Bal vs Phi |
| 45 | Rico Dowdle | Dal vs NYG |
| 46 | Trey McBride | Ari @ Min |
| 47 | Jauan Jennings | SF @ Buf |
| 48 | Brian Thomas Jr. | Jax vs Hou |
| 49 | Brock Bowers | LV @ KC |
| 50 | D'Andre Swift | Chi @ Det |
| 51 | Kareem Hunt (P) | KC vs LV |
| 52 | DK Metcalf | Sea @ NYJ |
| 53 | Bucky Irving | TB @ Car |
| 54 | Najee Harris | Pit @ Cin |
| 55 | Calvin Ridley | Ten @ Wsh |
| 56 | Darnell Mooney (Q) | Atl vs LAC |
| 57 | Nick Chubb | Cle @ Den |
| 58 | Taysom Hill | NO vs LAR |
| 59 | Jayden Reed | GB vs Mia |
| 60 | DeVonta Smith (Q) | Phi @ Bal |
| 61 | Rachaad White | TB @ Car |
| 62 | David Montgomery (Q) | Det vs Chi |
| 63 | Marvin Harrison Jr. | Ari @ Min |
| 64 | Jakobi Meyers | LV @ KC |
| 65 | DJ Moore | Chi @ Det |
| 66 | Deebo Samuel | SF @ Buf |
| 67 | Tank Dell | Hou @ Jax |
| 68 | Jordan Addison | Min vs Ari |
| 69 | Jameson Williams | Det vs Chi |
| 70 | Khalil Shakir | Buf vs SF |
