All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Wed 12:11 PM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | SF @ Buf |
| 2 | Alvin Kamara | NO vs LAR |
| 3 | Joe Mixon | Hou @ Jax |
| 4 | Bijan Robinson | Atl vs LAC |
| 5 | Jahmyr Gibbs | Det vs Chi |
| 6 | Saquon Barkley | Phi @ Bal |
| 7 | Chase Brown | Cin vs Pit |
| 8 | Kyren Williams | LAR @ NO |
| 9 | Breece Hall | NYJ vs Sea |
| 10 | Derrick Henry | Bal vs Phi |
| 11 | De'Von Achane | Mia @ GB |
| 12 | Josh Jacobs | GB vs Mia |
| 13 | Kenneth Walker III | Sea @ NYJ |
| 14 | Aaron Jones | Min vs Ari |
| 15 | Jonathan Taylor | Ind @ NE |
| 16 | Chuba Hubbard | Car vs TB |
| 17 | James Cook | Buf vs SF |
| 18 | James Conner | Ari @ Min |
| 19 | Tyrone Tracy Jr. | NYG @ Dal |
| 20 | Tony Pollard | Ten @ Wsh |
| Rank | Player | Match |
| 21 | Rhamondre Stevenson | NE vs Ind |
| 22 | Rico Dowdle | Dal vs NYG |
| 23 | D'Andre Swift | Chi @ Det |
| 24 | Kareem Hunt (P) | KC vs LV |
| 25 | Bucky Irving | TB @ Car |
| 26 | Najee Harris | Pit @ Cin |
| 27 | Nick Chubb | Cle @ Den |
| 28 | Rachaad White | TB @ Car |
| 29 | David Montgomery (Q) | Det vs Chi |
| 30 | Jaylen Warren | Pit @ Cin |
| 31 | Javonte Williams | Den vs Cle |
| 32 | Travis Etienne | Jax vs Hou |
| 33 | Isiah Pacheco (Q) | KC vs LV |
| 34 | Brian Robinson (Q) | Wsh vs Ten |
| 35 | Gus Edwards | LAC @ Atl |
| 36 | Jeremy McNichols | Wsh vs Ten |
| 37 | Tank Bigsby (Q) | Jax vs Hou |
| 38 | Tyjae Spears (Q) | Ten @ Wsh |
| 39 | Ameer Abdullah | LV @ KC |
| 40 | Austin Ekeler (Q) | Wsh vs Ten |
