All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sat 9:57 AM ET.
| Rank | Player | Match |
| 1 | Alvin Kamara | NO vs LAR |
| 2 | Joe Mixon | Hou @ Jax |
| 3 | Christian McCaffrey | SF @ Buf |
| 4 | Bijan Robinson | Atl vs LAC |
| 5 | Saquon Barkley | Phi @ Bal |
| 6 | Chase Brown | Cin vs Pit |
| 7 | Derrick Henry | Bal vs Phi |
| 8 | Kyren Williams | LAR @ NO |
| 9 | Breece Hall (Q) | NYJ vs Sea |
| 10 | Kenneth Walker III | Sea @ NYJ |
| 11 | Jonathan Taylor | Ind @ NE |
| 12 | Aaron Jones | Min vs Ari |
| 13 | Chuba Hubbard | Car vs TB |
| 14 | James Cook | Buf vs SF |
| 15 | James Conner | Ari @ Min |
| 16 | Tony Pollard | Ten @ Wsh |
| 17 | Rhamondre Stevenson | NE vs Ind |
| 18 | Bucky Irving | TB @ Car |
| 19 | Brian Robinson | Wsh vs Ten |
| 20 | Najee Harris | Pit @ Cin |
| Rank | Player | Match |
| 21 | Nick Chubb | Cle @ Den |
| 22 | Rachaad White | TB @ Car |
| 23 | Gus Edwards | LAC @ Atl |
| 24 | Jaylen Warren | Pit @ Cin |
| 25 | Javonte Williams | Den vs Cle |
| 26 | Travis Etienne | Jax vs Hou |
| 27 | Tank Bigsby | Jax vs Hou |
| 28 | Jeremy McNichols | Wsh vs Ten |
| 29 | Tyler Allgeier | Atl vs LAC |
| 30 | Zach Charbonnet | Sea @ NYJ |
| 31 | Jerome Ford | Cle @ Den |
| 32 | Jaleel McLaughlin | Den vs Cle |
| 33 | Justice Hill | Bal vs Phi |
| 34 | Cam Akers | Min vs Ari |
| 35 | Tyjae Spears (Q) | Ten @ Wsh |
| 36 | Antonio Gibson | NE vs Ind |
| 37 | Braelon Allen | NYJ vs Sea |
| 38 | Trey Benson | Ari @ Min |
| 39 | Ray Davis | Buf vs SF |
| 40 | Kimani Vidal | LAC @ Atl |
