All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sat 9:45 AM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | SF vs Sea |
| 2 | Alvin Kamara | NO vs Cle |
| 3 | De'Von Achane | Mia vs LV |
| 4 | Joe Mixon | Hou @ Dal |
| 5 | Bijan Robinson | Atl @ Den |
| 6 | Jahmyr Gibbs | Det vs Jax |
| 7 | Kyren Williams | LAR @ NE |
| 8 | Breece Hall | NYJ vs Ind |
| 9 | Derrick Henry | Bal @ Pit |
| 10 | Chase Brown | Cin @ LAC |
| 11 | Jonathan Taylor | Ind @ NYJ |
| 12 | Aaron Jones | Min @ Ten |
| 13 | Josh Jacobs | GB @ Chi |
| 14 | Kenneth Walker III | Sea @ SF |
| 15 | J.K. Dobbins | LAC vs Cin |
| 16 | D'Andre Swift | Chi vs GB |
| 17 | Kareem Hunt | KC @ Buf |
| 18 | James Cook | Buf vs KC |
| 19 | David Montgomery | Det vs Jax |
| 20 | Nick Chubb | Cle vs Pit |
| Rank | Player | Match |
| 21 | Rhamondre Stevenson | NE vs LAR |
| 22 | Tony Pollard | Ten vs Min |
| 23 | Najee Harris | Pit vs Bal |
| 24 | Rico Dowdle | Dal vs Hou |
| 25 | Travis Etienne | Jax @ Det |
| 26 | Alexander Mattison | LV @ Mia |
| 27 | Audric Estime | Den vs Atl |
| 28 | Jaylen Warren (Q) | Pit vs Bal |
| 29 | Tyjae Spears | Ten vs Min |
| 30 | Raheem Mostert | Mia vs LV |
| 31 | Javonte Williams | Den vs Atl |
| 32 | Braelon Allen | NYJ vs Ind |
| 33 | Tyler Allgeier | Atl @ Den |
| 34 | Gus Edwards | LAC vs Cin |
| 35 | Jerome Ford | Cle vs Pit |
| 36 | Zach Charbonnet | Sea @ SF |
| 37 | Justice Hill | Bal @ Pit |
| 38 | Ray Davis | Buf vs KC |
| 39 | Jaylen Wright | Mia vs LV |
| 40 | Emanuel Wilson | GB @ Chi |
