All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sat 9:45 AM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | SF vs Sea |
| 2 | Alvin Kamara | NO vs Cle |
| 3 | De'Von Achane | Mia vs LV |
| 4 | Joe Mixon | Hou @ Dal |
| 5 | Bijan Robinson | Atl @ Den |
| 6 | Jahmyr Gibbs | Det vs Jax |
| 7 | Ja'Marr Chase | Cin @ LAC |
| 8 | Kyren Williams | LAR @ NE |
| 9 | Breece Hall | NYJ vs Ind |
| 10 | Derrick Henry | Bal @ Pit |
| 11 | Amon-Ra St. Brown | Det vs Jax |
| 12 | Chase Brown | Cin @ LAC |
| 13 | Nico Collins (P) | Hou @ Dal |
| 14 | Justin Jefferson | Min @ Ten |
| 15 | Jonathan Taylor | Ind @ NYJ |
| 16 | Aaron Jones | Min @ Ten |
| 17 | Josh Jacobs | GB @ Chi |
| 18 | Kenneth Walker III | Sea @ SF |
| 19 | Garrett Wilson | NYJ vs Ind |
| 20 | Tyreek Hill | Mia vs LV |
| 21 | J.K. Dobbins | LAC vs Cin |
| 22 | Davante Adams (Q) | NYJ vs Ind |
| 23 | CeeDee Lamb | Dal vs Hou |
| 24 | D'Andre Swift | Chi vs GB |
| 25 | Kareem Hunt | KC @ Buf |
| 26 | Cooper Kupp | LAR @ NE |
| 27 | James Cook | Buf vs KC |
| 28 | David Montgomery | Det vs Jax |
| 29 | George Pickens | Pit vs Bal |
| 30 | Puka Nacua | LAR @ NE |
| 31 | George Kittle (Q) | SF vs Sea |
| 32 | Nick Chubb | Cle vs Pit |
| 33 | Drake London | Atl @ Den |
| 34 | Rhamondre Stevenson | NE vs LAR |
| 35 | Deebo Samuel | SF vs Sea |
| Rank | Player | Match |
| 36 | Travis Kelce | KC @ Buf |
| 37 | DK Metcalf | Sea @ SF |
| 38 | Tony Pollard | Ten vs Min |
| 39 | Zay Flowers | Bal @ Pit |
| 40 | Tee Higgins | Cin @ LAC |
| 41 | Courtland Sutton | Den vs Atl |
| 42 | Ladd McConkey | LAC vs Cin |
| 43 | Tank Dell | Hou @ Dal |
| 44 | Brock Bowers | LV @ Mia |
| 45 | Jayden Reed | GB @ Chi |
| 46 | Khalil Shakir | Buf vs KC |
| 47 | Najee Harris | Pit vs Bal |
| 48 | Cedric Tillman | Cle vs Pit |
| 49 | Rico Dowdle | Dal vs Hou |
| 50 | Jauan Jennings | SF vs Sea |
| 51 | Jakobi Meyers | LV @ Mia |
| 52 | Darnell Mooney | Atl @ Den |
| 53 | Travis Etienne | Jax @ Det |
| 54 | Calvin Ridley | Ten vs Min |
| 55 | Jaxon Smith-Njigba | Sea @ SF |
| 56 | DeAndre Hopkins | KC @ Buf |
| 57 | Brian Thomas Jr. | Jax @ Det |
| 58 | David Njoku | Cle vs Pit |
| 59 | Alexander Mattison | LV @ Mia |
| 60 | Jameson Williams | Det vs Jax |
| 61 | DJ Moore | Chi vs GB |
| 62 | Jaylen Waddle | Mia vs LV |
| 63 | Evan Engram | Jax @ Det |
| 64 | Quentin Johnston | LAC vs Cin |
| 65 | Josh Downs | Ind @ NYJ |
| 66 | Jerry Jeudy | Cle vs Pit |
| 67 | Romeo Doubs | GB @ Chi |
| 68 | T.J. Hockenson | Min @ Ten |
| 69 | Amari Cooper (Q) | Buf vs KC |
| 70 | Tyler Lockett | Sea @ SF |
