All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Thu 9:58 AM ET.
| Rank | Player | Match |
| 1 | Austin Ekeler | LAC vs Mia |
| 2 | Christian McCaffrey | SF @ Pit |
| 3 | Tony Pollard | Dal @ NYG |
| 4 | Bijan Robinson | Atl vs Car |
| 5 | Saquon Barkley | NYG vs Dal |
| 6 | Nick Chubb | Cle vs Cin |
| 7 | Derrick Henry | Ten @ NO |
| 8 | Josh Jacobs | LV @ Den |
| 9 | Joe Mixon | Cin @ Cle |
| 10 | Rhamondre Stevenson | NE vs Phi |
| 11 | Aaron Jones | GB @ Chi |
| 12 | Travis Etienne | Jax @ Ind |
| 13 | Alexander Mattison | Min vs TB |
| 14 | Kenneth Walker III | Sea vs LAR |
| 15 | Rachaad White | TB @ Min |
| 16 | Dameon Pierce | Hou @ Bal |
| 17 | J.K. Dobbins | Bal vs Hou |
| 18 | Jahmyr Gibbs | Det @ KC |
| 19 | James Conner | Ari @ Wsh |
| 20 | Miles Sanders | Car @ Atl |
| Rank | Player | Match |
| 21 | Najee Harris | Pit vs SF |
| 22 | Isiah Pacheco | KC vs Det |
| 23 | Raheem Mostert | Mia @ LAC |
| 24 | Cam Akers | LAR @ Sea |
| 25 | David Montgomery | Det @ KC |
| 26 | Dalvin Cook | NYJ vs Buf |
| 27 | Antonio Gibson | Wsh vs Ari |
| 28 | Samaje Perine | Den vs LV |
| 29 | Breece Hall (GTD) | NYJ vs Buf |
| 30 | Javonte Williams | Den vs LV |
| 31 | James Cook | Buf @ NYJ |
| 32 | Khalil Herbert | Chi vs GB |
| 33 | Brian Robinson | Wsh vs Ari |
| 34 | Deon Jackson | Ind vs Jax |
| 35 | Jamaal Williams | NO vs Ten |
| 36 | A.J. Dillon | GB @ Chi |
| 37 | D'Andre Swift | Phi @ NE |
| 38 | Devon Achane | Mia @ LAC |
| 39 | Jerick McKinnon | KC vs Det |
| 40 | Evan Hull | Ind vs Jax |
