All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Thu 12:18 PM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | SF vs Wsh |
| 2 | Austin Ekeler | LAC @ Ind |
| 3 | Derrick Henry | Ten vs Hou |
| 4 | Josh Jacobs | LV @ Pit |
| 5 | Saquon Barkley | NYG @ Min |
| 6 | Dalvin Cook | Min vs NYG |
| 7 | Alvin Kamara | NO @ Cle |
| 8 | James Conner | Ari vs TB |
| 9 | Nick Chubb (GTD) | Cle vs NO |
| 10 | Rhamondre Stevenson (GTD) | NE vs Cin |
| 11 | Aaron Jones | GB @ Mia |
| 12 | Tony Pollard | Dal vs Phi |
| 13 | Joe Mixon | Cin @ NE |
| 14 | Travis Etienne | Jax @ NYJ |
| 15 | Najee Harris | Pit vs LV |
| 16 | David Montgomery | Chi vs Buf |
| 17 | J.K. Dobbins | Bal vs Atl |
| 18 | Kenneth Walker III | Sea @ KC |
| 19 | Miles Sanders | Phi @ Dal |
| 20 | Jerick McKinnon | KC vs Sea |
| Rank | Player | Match |
| 21 | Latavius Murray | Den @ LAR |
| 22 | Raheem Mostert | Mia vs GB |
| 23 | Ezekiel Elliott | Dal vs Phi |
| 24 | Leonard Fournette | TB @ Ari |
| 25 | D'Andre Swift | Det @ Car |
| 26 | Rachaad White | TB @ Ari |
| 27 | Devin Singletary | Buf @ Chi |
| 28 | Jamaal Williams | Det @ Car |
| 29 | Isiah Pacheco | KC vs Sea |
| 30 | D'Onta Foreman | Car vs Det |
| 31 | Cordarrelle Patterson | Atl @ Bal |
| 32 | Zonovan Knight | NYJ vs Jax |
| 33 | Zack Moss | Ind vs LAC |
| 34 | A.J. Dillon | GB @ Mia |
| 35 | Brian Robinson | Wsh @ SF |
| 36 | Cam Akers | LAR vs Den |
| 37 | Michael Carter | NYJ vs Jax |
| 38 | Antonio Gibson (GTD) | Wsh @ SF |
| 39 | Chuba Hubbard | Car vs Det |
| 40 | Tyler Allgeier | Atl @ Bal |
