All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sun 9:38 AM ET.
| Rank | Player | Match |
| 1 | Derrick Henry | Ten @ Hou |
| 2 | Saquon Barkley | NYG @ Sea |
| 3 | Christian McCaffrey | SF @ LAR |
| 4 | Josh Jacobs | LV @ NO |
| 5 | Alvin Kamara | NO vs LV |
| 6 | Jonathan Taylor | Ind vs Wsh |
| 7 | Tony Pollard | Dal vs Chi |
| 8 | Joe Mixon | Cin @ Cle |
| 9 | Nick Chubb | Cle vs Cin |
| 10 | Kenneth Walker III | Sea vs NYG |
| 11 | Dameon Pierce | Hou vs Ten |
| 12 | Dalvin Cook | Min vs Ari |
| 13 | Rhamondre Stevenson | NE @ NYJ |
| 14 | Aaron Jones | GB @ Buf |
| 15 | D'Andre Swift | Det vs Mia |
| 16 | Raheem Mostert | Mia @ Det |
| 17 | Miles Sanders | Phi vs Pit |
| 18 | Eno Benjamin | Ari @ Min |
| 19 | D'Onta Foreman | Car @ Atl |
| 20 | Najee Harris | Pit @ Phi |
| Rank | Player | Match |
| 21 | Devin Singletary | Buf vs GB |
| 22 | Michael Carter | NYJ vs NE |
| 23 | David Montgomery | Chi @ Dal |
| 24 | Darrell Henderson | LAR vs SF |
| 25 | Tyler Allgeier | Atl vs Car |
| 26 | Brian Robinson | Wsh @ Ind |
| 27 | Kareem Hunt | Cle vs Cin |
| 28 | Jamaal Williams | Det vs Mia |
| 29 | A.J. Dillon | GB @ Buf |
| 30 | Antonio Gibson | Wsh @ Ind |
| 31 | Rex Burkhead | Hou vs Ten |
| 32 | Damien Harris | NE @ NYJ |
| 33 | Nyheim Hines | Ind vs Wsh |
| 34 | James Robinson | NYJ vs NE |
| 35 | Khalil Herbert | Chi @ Dal |
| 36 | Chase Edmonds | Mia @ Det |
| 37 | Dontrell Hilliard | Ten @ Hou |
| 38 | Alexander Mattison | Min vs Ari |
| 39 | Caleb Huntley | Atl vs Car |
| 40 | Malik Davis | Dal vs Chi |
