All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sun 9:14 AM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | Car @ Mia |
| 2 | Jonathan Taylor | Ind vs TB |
| 3 | Austin Ekeler | LAC @ Den |
| 4 | Dalvin Cook | Min @ SF |
| 5 | Najee Harris | Pit @ Cin |
| 6 | Joe Mixon | Cin vs Pit |
| 7 | Saquon Barkley (Q) | NYG vs Phi |
| 8 | James Robinson | Jax vs Atl |
| 9 | Cordarrelle Patterson (GTD) | Atl @ Jax |
| 10 | Darrell Henderson | LAR @ GB |
| 11 | Leonard Fournette | TB @ Ind |
| 12 | Nick Chubb | Cle @ Bal |
| 13 | Antonio Gibson | Wsh vs Sea |
| 14 | Myles Gaskin | Mia vs Car |
| 15 | Miles Sanders | Phi @ NYG |
| 16 | Melvin Gordon | Den vs LAC |
| 17 | Eli Mitchell (GTD) | SF vs Min |
| 18 | A.J. Dillon | GB vs LAR |
| 19 | Aaron Jones (GTD) | GB vs LAR |
| 20 | Javonte Williams | Den vs LAC |
| Rank | Player | Match |
| 21 | David Johnson | Hou vs NYJ |
| 22 | Rhamondre Stevenson (GTD) | NE vs Ten |
| 23 | Kareem Hunt | Cle @ Bal |
| 24 | Ty Johnson | NYJ @ Hou |
| 25 | Devonta Freeman | Bal vs Cle |
| 26 | Damien Harris | NE vs Ten |
| 27 | D'Onta Foreman | Ten @ NE |
| 28 | Dontrell Hilliard | Ten @ NE |
| 29 | Alex Collins | Sea @ Wsh |
| 30 | Rex Burkhead | Hou vs NYJ |
| 31 | Tevin Coleman | NYJ @ Hou |
| 32 | Jeff Wilson | SF vs Min |
| 33 | J.D. McKissic | Wsh vs Sea |
| 34 | Latavius Murray | Bal vs Cle |
| 35 | Boston Scott | Phi @ NYG |
| 36 | DeeJay Dallas | Sea @ Wsh |
| 37 | Nyheim Hines | Ind vs TB |
| 38 | Mike Davis | Atl @ Jax |
| 39 | Sony Michel | LAR @ GB |
| 40 | Brandon Bolden | NE vs Ten |
