All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Thu 1:55 PM ET.
| Rank | Player | Match |
| 1 | Derrick Henry | Ten @ Cin |
| 2 | Alvin Kamara | NO @ Chi |
| 3 | Kareem Hunt (que) | Cle vs LV |
| 4 | Davante Adams | GB vs Min |
| 5 | Dalvin Cook (GTD) | Min @ GB |
| 6 | Josh Jacobs (que) | LV @ Cle |
| 7 | Jonathan Taylor | Ind @ Det |
| 8 | Tyreek Hill | KC vs NYJ |
| 9 | Aaron Jones (GTD) | GB vs Min |
| 10 | Ezekiel Elliott | Dal @ Phi |
| 11 | Tyler Lockett | Sea vs SF |
| 12 | Todd Gurley | Atl @ Car |
| 13 | D.K. Metcalf | Sea vs SF |
| 14 | George Kittle | SF @ Sea |
| 15 | Calvin Ridley | Atl @ Car |
| 16 | Clyde Edwards-Helaire | KC vs NYJ |
| 17 | Travis Kelce | KC vs NYJ |
| 18 | Stefon Diggs | Buf vs NE |
| 19 | Julio Jones | Atl @ Car |
| 20 | Mike Davis | Car vs Atl |
| 21 | Adam Thielen | Min @ GB |
| 22 | Keenan Allen | LAC @ Den |
| 23 | Mike Evans | TB @ NYG |
| 24 | Allen Robinson (que) | Chi vs NO |
| 25 | A.J. Brown | Ten @ Cin |
| 26 | David Montgomery | Chi vs NO |
| 27 | Miles Sanders (GTD) | Phi vs Dal |
| 28 | James Conner | Pit @ Bal |
| 29 | Kenny Golladay | Det vs Ind |
| 30 | Robby Anderson | Car vs Atl |
| 31 | D.J. Moore | Car vs Atl |
| 32 | Joe Mixon (GTD) | Cin vs Ten |
| 33 | Christian McCaffrey (GTD) | Car vs Atl |
| 34 | Cooper Kupp | LAR @ Mia |
| 35 | Darrell Henderson | LAR @ Mia |
| Rank | Player | Match |
| 36 | Myles Gaskin | Mia vs LAR |
| 37 | Tyler Boyd | Cin vs Ten |
| 38 | Robert Woods | LAR @ Mia |
| 39 | Melvin Gordon | Den vs LAC |
| 40 | Michael Thomas (GTD) | NO @ Chi |
| 41 | Darren Waller | LV @ Cle |
| 42 | Ronald Jones | TB @ NYG |
| 43 | Justin Jefferson | Min @ GB |
| 44 | Mark Andrews | Bal vs Pit |
| 45 | Brandon Aiyuk | SF @ Sea |
| 46 | Amari Cooper | Dal @ Phi |
| 47 | Jerick McKinnon | SF @ Sea |
| 48 | DeVante Parker (que) | Mia vs LAR |
| 49 | Tee Higgins | Cin vs Ten |
| 50 | Jarvis Landry (que) | Cle vs LV |
| 51 | Travis Fulgham | Phi vs Dal |
| 52 | Marquise Brown | Bal vs Pit |
| 53 | T.Y. Hilton | Ind @ Det |
| 54 | D'Andre Swift | Det vs Ind |
| 55 | Devin Singletary | Buf vs NE |
| 56 | A.J. Green | Cin vs Ten |
| 57 | Hunter Henry | LAC @ Den |
| 58 | Darius Slayton | NYG vs TB |
| 59 | Mike Williams | LAC @ Den |
| 60 | Chase Claypool | Pit @ Bal |
| 61 | Jamaal Williams | GB vs Min |
| 62 | JuJu Smith-Schuster (que) | Pit @ Bal |
| 63 | Rob Gronkowski | TB @ NYG |
| 64 | Le'Veon Bell | KC vs NYJ |
| 65 | Joshua Kelley | LAC @ Den |
| 66 | Jerry Jeudy | Den vs LAC |
| 67 | T.J. Hockenson | Det vs Ind |
| 68 | Scotty Miller | TB @ NYG |
| 69 | Marvin Jones | Det vs Ind |
| 70 | Jamison Crowder (GTD) | NYJ @ KC |
