All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Thu 1:55 PM ET.
| Rank | Player | Match |
| 1 | Derrick Henry | Ten @ Cin |
| 2 | Alvin Kamara | NO @ Chi |
| 3 | Kareem Hunt (que) | Cle vs LV |
| 4 | Dalvin Cook (GTD) | Min @ GB |
| 5 | Josh Jacobs (que) | LV @ Cle |
| 6 | Jonathan Taylor | Ind @ Det |
| 7 | Aaron Jones (GTD) | GB vs Min |
| 8 | Ezekiel Elliott | Dal @ Phi |
| 9 | Todd Gurley | Atl @ Car |
| 10 | Clyde Edwards-Helaire | KC vs NYJ |
| 11 | Mike Davis | Car vs Atl |
| 12 | David Montgomery | Chi vs NO |
| 13 | Miles Sanders (GTD) | Phi vs Dal |
| 14 | James Conner | Pit @ Bal |
| 15 | Joe Mixon (GTD) | Cin vs Ten |
| 16 | Christian McCaffrey (GTD) | Car vs Atl |
| 17 | Darrell Henderson | LAR @ Mia |
| 18 | Myles Gaskin | Mia vs LAR |
| 19 | Melvin Gordon | Den vs LAC |
| 20 | Ronald Jones | TB @ NYG |
| Rank | Player | Match |
| 21 | Jerick McKinnon | SF @ Sea |
| 22 | D'Andre Swift | Det vs Ind |
| 23 | Devin Singletary | Buf vs NE |
| 24 | Jamaal Williams | GB vs Min |
| 25 | Le'Veon Bell | KC vs NYJ |
| 26 | Joshua Kelley | LAC @ Den |
| 27 | Carlos Hyde (que) | Sea vs SF |
| 28 | Leonard Fournette | TB @ NYG |
| 29 | Justin Jackson (GTD) | LAC @ Den |
| 30 | Devonta Freeman (GTD) | NYG vs TB |
| 31 | James White | NE @ Buf |
| 32 | J.K. Dobbins | Bal vs Pit |
| 33 | Damien Harris (que) | NE @ Buf |
| 34 | La'Mical Perine | NYJ @ KC |
| 35 | Adrian Peterson | Det vs Ind |
| 36 | Latavius Murray | NO @ Chi |
| 37 | Nyheim Hines | Ind @ Det |
| 38 | Malcolm Brown | LAR @ Mia |
| 39 | Rex Burkhead | NE @ Buf |
| 40 | Giovani Bernard | Cin vs Ten |
