All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sat 1:58 PM ET.
| Rank | Player | Match |
| 1 | Ezekiel Elliott | Dal vs Ari |
| 2 | Derrick Henry | Ten vs Hou |
| 3 | Kareem Hunt | Cle @ Pit |
| 4 | Alexander Mattison | Min vs Atl |
| 5 | Aaron Jones | GB @ TB |
| 6 | Mike Davis | Car vs Chi |
| 7 | Miles Sanders | Phi vs Bal |
| 8 | Clyde Edwards-Helaire | KC @ Buf |
| 9 | Jonathan Taylor | Ind vs Cin |
| 10 | David Montgomery | Chi @ Car |
| 11 | James Robinson | Jax vs Det |
| 12 | James Conner | Pit vs Cle |
| 13 | Joe Mixon | Cin @ Ind |
| 14 | Todd Gurley | Atl @ Min |
| 15 | Raheem Mostert | SF vs LAR |
| 16 | Myles Gaskin | Mia vs NYJ |
| 17 | Ronald Jones | TB vs GB |
| 18 | David Johnson | Hou @ Ten |
| 19 | Antonio Gibson | Wsh @ NYG |
| 20 | Devin Singletary | Buf vs KC |
| Rank | Player | Match |
| 21 | Kenyan Drake | Ari @ Dal |
| 22 | Devonta Freeman | NYG vs Wsh |
| 23 | Darrell Henderson | LAR @ SF |
| 24 | Adrian Peterson | Det @ Jax |
| 25 | Frank Gore | NYJ @ Mia |
| 26 | Mark Ingram | Bal @ Phi |
| 27 | Jerick McKinnon | SF vs LAR |
| 28 | Chase Edmonds | Ari @ Dal |
| 29 | Jamaal Williams | GB @ TB |
| 30 | Nyheim Hines | Ind vs Cin |
| 31 | J.D. McKissic | Wsh @ NYG |
| 32 | La'Mical Perine | NYJ @ Mia |
| 33 | Phillip Lindsay | Den @ NE |
| 34 | D'Andre Swift | Det @ Jax |
| 35 | Duke Johnson | Hou @ Ten |
| 36 | Chris Thompson | Jax vs Det |
| 37 | Leonard Fournette (que) | TB vs GB |
| 38 | James White | NE vs Den |
| 39 | Mike Boone | Min vs Atl |
| 40 | Malcolm Brown | LAR @ SF |
