All position ranks are: QB RB WR TE FLEX D
These rankings were updated as of Sun 11:01 AM ET.
| Rank | Player | Match |
| 1 | Alvin Kamara | NO vs GB |
| 2 | Ezekiel Elliott | Dal @ Sea |
| 3 | Miles Sanders | Phi vs Cin |
| 4 | Derrick Henry | Ten @ Min |
| 5 | Dalvin Cook | Min vs Ten |
| 6 | Aaron Jones | GB @ NO |
| 7 | Jonathan Taylor | Ind vs NYJ |
| 8 | Kenyan Drake | Ari vs Det |
| 9 | Chris Carson | Sea vs Dal |
| 10 | Austin Ekeler | LAC vs Car |
| 11 | Josh Jacobs (que) | LV @ NE |
| 12 | Clyde Edwards-Helaire | KC @ Bal |
| 13 | Joe Mixon | Cin @ Phi |
| 14 | James Conner | Pit vs Hou |
| 15 | Nick Chubb | Cle vs Wsh |
| 16 | Devin Singletary | Buf vs LAR |
| 17 | Melvin Gordon | Den vs TB |
| 18 | Todd Gurley | Atl vs Chi |
| 19 | David Johnson | Hou @ Pit |
| 20 | Jerick McKinnon | SF @ NYG |
| Rank | Player | Match |
| 21 | David Montgomery (GTD) | Chi @ Atl |
| 22 | Kareem Hunt | Cle vs Wsh |
| 23 | Mike Davis | Car @ LAC |
| 24 | Darrell Henderson | LAR @ Buf |
| 25 | Mark Ingram | Bal vs KC |
| 26 | Joshua Kelley | LAC vs Car |
| 27 | Rex Burkhead | NE vs LV |
| 28 | Antonio Gibson | Wsh @ Cle |
| 29 | Ronald Jones | TB @ Den |
| 30 | Leonard Fournette | TB @ Den |
| 31 | Dion Lewis | NYG vs SF |
| 32 | Nyheim Hines | Ind vs NYJ |
| 33 | Frank Gore | NYJ @ Ind |
| 34 | Sony Michel | NE vs LV |
| 35 | D'Andre Swift | Det @ Ari |
| 36 | Tarik Cohen | Chi @ Atl |
| 37 | Malcolm Brown | LAR @ Buf |
| 38 | Jeff Wilson | SF @ NYG |
| 39 | Latavius Murray | NO vs GB |
| 40 | Adrian Peterson | Det @ Ari |
