All position rankings are: QB | RB | WR | TE | FLEX | D
These rankings were updated as of Sun 8:36 AM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | Car vs Sea |
| 2 | Michael Thomas | NO vs Ind |
| 3 | Dalvin Cook | Min @ LAC |
| 4 | Saquon Barkley | NYG vs Mia |
| 5 | Alvin Kamara | NO vs Ind |
| 6 | Leonard Fournette | Jax @ Oak |
| 7 | Ezekiel Elliott | Dal vs LAR |
| 8 | Derrick Henry (que) | Ten vs Hou |
| 9 | DeAndre Hopkins | Hou @ Ten |
| 10 | Chris Godwin | TB @ Det |
| 11 | Chris Carson | Sea @ Car |
| 12 | Nick Chubb | Cle @ Ari |
| 13 | Tyreek Hill | KC vs Den |
| 14 | Davante Adams | GB vs Chi |
| 15 | Todd Gurley | LAR @ Dal |
| 16 | Julio Jones | Atl @ SF |
| 17 | Aaron Jones | GB vs Chi |
| 18 | Melvin Gordon | LAC vs Min |
| 19 | Josh Jacobs (que) | Oak vs Jax |
| 20 | Julian Edelman (que) | NE @ Cin |
| 21 | Kenny Golladay | Det vs TB |
| 22 | Travis Kelce | KC vs Den |
| 23 | Amari Cooper | Dal vs LAR |
| 24 | George Kittle | SF vs Atl |
| 25 | Miles Sanders | Phi @ Wsh |
| 26 | D.J. Moore | Car vs Sea |
| 27 | Austin Ekeler | LAC vs Min |
| 28 | Keenan Allen | LAC vs Min |
| 29 | James Conner (que) | Pit vs Buf |
| 30 | Zach Ertz | Phi @ Wsh |
| 31 | Jarvis Landry | Cle @ Ari |
| 32 | Joe Mixon | Cin vs NE |
| 33 | Robert Woods | LAR @ Dal |
| 34 | Courtland Sutton | Den @ KC |
| 35 | Cooper Kupp | LAR @ Dal |
| Rank | Player | Match |
| 36 | Tyler Lockett | Sea @ Car |
| 37 | Devonta Freeman | Atl @ SF |
| 38 | Phillip Lindsay | Den @ KC |
| 39 | Allen Robinson | Chi @ GB |
| 40 | Odell Beckham | Cle @ Ari |
| 41 | Devin Singletary | Buf @ Pit |
| 42 | Darren Waller | Oak vs Jax |
| 43 | Christian Kirk | Ari vs Cle |
| 44 | Stefon Diggs | Min @ LAC |
| 45 | Kenyan Drake | Ari vs Cle |
| 46 | Raheem Mostert | SF vs Atl |
| 47 | DeVante Parker | Mia @ NYG |
| 48 | A.J. Brown | Ten vs Hou |
| 49 | Michael Gallup | Dal vs LAR |
| 50 | Austin Hooper | Atl @ SF |
| 51 | Emmanuel Sanders | SF vs Atl |
| 52 | James White | NE @ Cin |
| 53 | Adam Thielen | Min @ LAC |
| 54 | Patrick Laird | Mia @ NYG |
| 55 | Tyler Boyd | Cin vs NE |
| 56 | Kareem Hunt | Cle @ Ari |
| 57 | Marlon Mack | Ind @ NO |
| 58 | David Montgomery (GTD) | Chi @ GB |
| 59 | D.K. Metcalf | Sea @ Car |
| 60 | Terry McLaurin | Wsh vs Phi |
| 61 | Hunter Henry | LAC vs Min |
| 62 | John Brown | Buf @ Pit |
| 63 | Deebo Samuel | SF vs Atl |
| 64 | Will Fuller (que) | Hou @ Ten |
| 65 | Sterling Shepard | NYG vs Mia |
| 66 | Golden Tate | NYG vs Mia |
| 67 | Tyrell Williams | Oak vs Jax |
| 68 | Dede Westbrook | Jax @ Oak |
| 69 | Carlos Hyde | Hou @ Ten |
| 70 | Darius Slayton | NYG vs Mia |
