All position rankings are: QB | RB | WR | TE | FLEX | D
These rankings were updated as of Sun 8:36 AM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | Car vs Sea |
| 2 | Dalvin Cook | Min @ LAC |
| 3 | Saquon Barkley | NYG vs Mia |
| 4 | Alvin Kamara | NO vs Ind |
| 5 | Leonard Fournette | Jax @ Oak |
| 6 | Ezekiel Elliott | Dal vs LAR |
| 7 | Derrick Henry (que) | Ten vs Hou |
| 8 | Chris Carson | Sea @ Car |
| 9 | Nick Chubb | Cle @ Ari |
| 10 | Todd Gurley | LAR @ Dal |
| 11 | Aaron Jones | GB vs Chi |
| 12 | Melvin Gordon | LAC vs Min |
| 13 | Josh Jacobs (que) | Oak vs Jax |
| 14 | Miles Sanders | Phi @ Wsh |
| 15 | Austin Ekeler | LAC vs Min |
| 16 | James Conner (que) | Pit vs Buf |
| 17 | Joe Mixon | Cin vs NE |
| 18 | Devonta Freeman | Atl @ SF |
| 19 | Phillip Lindsay | Den @ KC |
| 20 | Devin Singletary | Buf @ Pit |
| Rank | Player | Match |
| 21 | Kenyan Drake | Ari vs Cle |
| 22 | Raheem Mostert | SF vs Atl |
| 23 | James White | NE @ Cin |
| 24 | Patrick Laird | Mia @ NYG |
| 25 | Kareem Hunt | Cle @ Ari |
| 26 | Marlon Mack | Ind @ NO |
| 27 | David Montgomery (GTD) | Chi @ GB |
| 28 | Carlos Hyde | Hou @ Ten |
| 29 | Adrian Peterson | Wsh vs Phi |
| 30 | Jamaal Williams | GB vs Chi |
| 31 | Ronald Jones | TB @ Det |
| 32 | Tarik Cohen | Chi @ GB |
| 33 | Sony Michel | NE @ Cin |
| 34 | Matt Breida | SF vs Atl |
| 35 | Duke Johnson | Hou @ Ten |
| 36 | Royce Freeman | Den @ KC |
| 37 | LeSean McCoy | KC vs Den |
| 38 | Chris Thompson | Wsh vs Phi |
| 39 | Latavius Murray | NO vs Ind |
| 40 | Nyheim Hines | Ind @ NO |
