All position rankings are: QB | RB | WR | TE | FLEX | D
These rankings were updated as of Sun 9:49 AM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | Car vs Wsh |
| 2 | Dalvin Cook | Min @ Sea |
| 3 | Leonard Fournette | Jax vs TB |
| 4 | Saquon Barkley | NYG vs GB |
| 5 | Tyreek Hill | KC vs Oak |
| 6 | Davante Adams | GB @ NYG |
| 7 | Le'Veon Bell | NYJ @ Cin |
| 8 | DeAndre Hopkins | Hou vs NE |
| 9 | Derrick Henry | Ten @ Ind |
| 10 | Todd Gurley | LAR @ Ari |
| 11 | Mike Evans | TB @ Jax |
| 12 | Chris Godwin | TB @ Jax |
| 13 | Tyler Lockett | Sea vs Min |
| 14 | Travis Kelce | KC vs Oak |
| 15 | Nick Chubb | Cle @ Pit |
| 16 | Julian Edelman (que) | NE @ Hou |
| 17 | Josh Jacobs | Oak @ KC |
| 18 | Cooper Kupp | LAR @ Ari |
| 19 | Aaron Jones | GB @ NYG |
| 20 | Melvin Gordon | LAC @ Den |
| 21 | Stefon Diggs | Min @ Sea |
| 22 | Adam Thielen (que) | Min @ Sea |
| 23 | Keenan Allen | LAC @ Den |
| 24 | D.J. Chark | Jax vs TB |
| 25 | Chris Carson | Sea vs Min |
| 26 | D.J. Moore | Car vs Wsh |
| 27 | George Kittle | SF @ Bal |
| 28 | Miles Sanders | Phi @ Mia |
| 29 | Tyler Boyd | Cin vs NYJ |
| 30 | Zach Ertz (que) | Phi @ Mia |
| 31 | Odell Beckham | Cle @ Pit |
| 32 | Phillip Lindsay | Den vs LAC |
| 33 | Courtland Sutton | Den vs LAC |
| 34 | Joe Mixon | Cin vs NYJ |
| 35 | Jonathan Williams | Ind vs Ten |
| Rank | Player | Match |
| 36 | Christian Kirk | Ari vs LAR |
| 37 | Jarvis Landry | Cle @ Pit |
| 38 | DeVante Parker | Mia vs Phi |
| 39 | Hunter Henry | LAC @ Den |
| 40 | Mark Ingram | Bal vs SF |
| 41 | Tevin Coleman | SF @ Bal |
| 42 | Robert Woods | LAR @ Ari |
| 43 | Austin Ekeler | LAC @ Den |
| 44 | Sterling Shepard | NYG vs GB |
| 45 | LeSean McCoy | KC vs Oak |
| 46 | Alshon Jeffery | Phi @ Mia |
| 47 | Mark Andrews | Bal vs SF |
| 48 | Jamison Crowder | NYJ @ Cin |
| 49 | Sammy Watkins | KC vs Oak |
| 50 | Darren Waller | Oak @ KC |
| 51 | Kenyan Drake | Ari vs LAR |
| 52 | D.K. Metcalf | Sea vs Min |
| 53 | Terry McLaurin | Wsh @ Car |
| 54 | James White | NE @ Hou |
| 55 | Tyrell Williams | Oak @ KC |
| 56 | Sony Michel | NE @ Hou |
| 57 | Ronald Jones | TB @ Jax |
| 58 | Benny Snell | Pit vs Cle |
| 59 | Jamaal Williams | GB @ NYG |
| 60 | Brandin Cooks | LAR @ Ari |
| 61 | Dede Westbrook | Jax vs TB |
| 62 | Darius Slayton | NYG vs GB |
| 63 | Will Fuller | Hou vs NE |
| 64 | Emmanuel Sanders | SF @ Bal |
| 65 | Mike Williams | LAC @ Den |
| 66 | Carlos Hyde | Hou vs NE |
| 67 | Kareem Hunt | Cle @ Pit |
| 68 | Diontae Johnson | Pit vs Cle |
| 69 | Curtis Samuel | Car vs Wsh |
| 70 | Zach Pascal | Ind vs Ten |