All position rankings are: QB | RB | WR | TE | FLEX | D
These rankings were updated as of Sun 9:49 AM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | Car vs Wsh |
| 2 | Dalvin Cook | Min @ Sea |
| 3 | Leonard Fournette | Jax vs TB |
| 4 | Saquon Barkley | NYG vs GB |
| 5 | Le'Veon Bell | NYJ @ Cin |
| 6 | Derrick Henry | Ten @ Ind |
| 7 | Todd Gurley | LAR @ Ari |
| 8 | Nick Chubb | Cle @ Pit |
| 9 | Josh Jacobs | Oak @ KC |
| 10 | Aaron Jones | GB @ NYG |
| 11 | Melvin Gordon | LAC @ Den |
| 12 | Chris Carson | Sea vs Min |
| 13 | Miles Sanders | Phi @ Mia |
| 14 | Phillip Lindsay | Den vs LAC |
| 15 | Joe Mixon | Cin vs NYJ |
| 16 | Jonathan Williams | Ind vs Ten |
| 17 | Mark Ingram | Bal vs SF |
| 18 | Tevin Coleman | SF @ Bal |
| 19 | Austin Ekeler | LAC @ Den |
| 20 | LeSean McCoy | KC vs Oak |
| Rank | Player | Match |
| 21 | Kenyan Drake | Ari vs LAR |
| 22 | James White | NE @ Hou |
| 23 | Sony Michel | NE @ Hou |
| 24 | Ronald Jones | TB @ Jax |
| 25 | Benny Snell | Pit vs Cle |
| 26 | Jamaal Williams | GB @ NYG |
| 27 | Carlos Hyde | Hou vs NE |
| 28 | Kareem Hunt | Cle @ Pit |
| 29 | Derrius Guice | Wsh @ Car |
| 30 | Royce Freeman | Den vs LAC |
| 31 | Darrel Williams | KC vs Oak |
| 32 | Nyheim Hines | Ind vs Ten |
| 33 | Matt Breida (que) | SF @ Bal |
| 34 | Duke Johnson | Hou vs NE |
| 35 | Kalen Ballage | Mia vs Phi |
| 36 | Jaylen Samuels | Pit vs Cle |
| 37 | Rashaad Penny | Sea vs Min |
| 38 | Adrian Peterson | Wsh @ Car |
| 39 | Jordan Scarlett (Out) | Car vs Wsh |
| 40 | Jalen Richard | Oak @ KC |