All position rankings are: QB | RB | WR | TE | FLEX | D
These rankings were updated as of Sat 10:36 AM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | Car @ SF |
| 2 | Saquon Barkley | NYG @ Det |
| 3 | James Conner (GTD) | Pit vs Mia |
| 4 | Leonard Fournette | Jax vs NYJ |
| 5 | Chris Carson | Sea @ Atl |
| 6 | Todd Gurley | LAR @ Cin |
| 7 | Le'Veon Bell | NYJ @ Jax |
| 8 | Alvin Kamara (que) | NO vs Ari |
| 9 | Nick Chubb | Cle @ NE |
| 10 | Aaron Jones | GB @ KC |
| 11 | Derrick Henry | Ten vs TB |
| 12 | Marlon Mack | Ind vs Den |
| 13 | Devonta Freeman | Atl vs Sea |
| 14 | Austin Ekeler | LAC @ Chi |
| 15 | Sony Michel | NE vs Cle |
| 16 | Chase Edmonds | Ari @ NO |
| 17 | Tevin Coleman | SF vs Car |
| 18 | James White | NE vs Cle |
| 19 | Phillip Lindsay | Den @ Ind |
| 20 | Ty Johnson | Det vs NYG |
| Rank | Player | Match |
| 21 | Carlos Hyde | Hou vs Oak |
| 22 | Josh Jacobs (que) | Oak @ Hou |
| 23 | David Montgomery | Chi vs LAC |
| 24 | Melvin Gordon | LAC @ Chi |
| 25 | Joe Mixon | Cin vs LAR |
| 26 | Royce Freeman | Den @ Ind |
| 27 | Matt Breida | SF vs Car |
| 28 | LeSean McCoy | KC vs GB |
| 29 | Jamaal Williams | GB @ KC |
| 30 | Latavius Murray | NO vs Ari |
| 31 | Tarik Cohen | Chi vs LAC |
| 32 | Kenyan Drake | Mia @ Pit |
| 33 | Ronald Jones | TB @ Ten |
| 34 | J.D. McKissic | Det vs NYG |
| 35 | David Johnson (que) | Ari @ NO |
| 36 | Jordan Howard | Phi @ Buf |
| 37 | Frank Gore | Buf vs Phi |
| 38 | Duke Johnson | Hou vs Oak |
| 39 | Damien Williams | KC vs GB |
| 40 | Devin Singletary | Buf vs Phi |
