All position rankings are: QB | RB | WR | TE | FLEX | D
These rankings were updated as of Sat 10:36 AM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | Car @ SF |
| 2 | Saquon Barkley | NYG @ Det |
| 3 | James Conner (GTD) | Pit vs Mia |
| 4 | Leonard Fournette | Jax vs NYJ |
| 5 | Michael Thomas | NO vs Ari |
| 6 | DeAndre Hopkins | Hou vs Oak |
| 7 | Chris Carson | Sea @ Atl |
| 8 | Todd Gurley | LAR @ Cin |
| 9 | Le'Veon Bell | NYJ @ Jax |
| 10 | Alvin Kamara (que) | NO vs Ari |
| 11 | Nick Chubb | Cle @ NE |
| 12 | Tyler Lockett | Sea @ Atl |
| 13 | Julio Jones | Atl vs Sea |
| 14 | Aaron Jones | GB @ KC |
| 15 | Cooper Kupp | LAR @ Cin |
| 16 | Derrick Henry | Ten vs TB |
| 17 | Kenny Golladay | Det vs NYG |
| 18 | Chris Godwin | TB @ Ten |
| 19 | Marlon Mack | Ind vs Den |
| 20 | Julian Edelman (que) | NE vs Cle |
| 21 | Devonta Freeman | Atl vs Sea |
| 22 | Mike Evans | TB @ Ten |
| 23 | T.Y. Hilton | Ind vs Den |
| 24 | Odell Beckham | Cle @ NE |
| 25 | Tyreek Hill | KC vs GB |
| 26 | Courtland Sutton | Den @ Ind |
| 27 | George Kittle | SF vs Car |
| 28 | Allen Robinson | Chi vs LAC |
| 29 | Tyler Boyd | Cin vs LAR |
| 30 | Austin Ekeler | LAC @ Chi |
| 31 | JuJu Smith-Schuster | Pit vs Mia |
| 32 | Darren Waller | Oak @ Hou |
| 33 | Sony Michel | NE vs Cle |
| 34 | Robert Woods | LAR @ Cin |
| 35 | Chase Edmonds | Ari @ NO |
| Rank | Player | Match |
| 36 | Tevin Coleman | SF vs Car |
| 37 | James White | NE vs Cle |
| 38 | Marvin Jones | Det vs NYG |
| 39 | Phillip Lindsay | Den @ Ind |
| 40 | Travis Kelce | KC vs GB |
| 41 | John Brown | Buf vs Phi |
| 42 | Austin Hooper | Atl vs Sea |
| 43 | D.J. Chark | Jax vs NYJ |
| 44 | Ty Johnson | Det vs NYG |
| 45 | Evan Engram | NYG @ Det |
| 46 | Keenan Allen (que) | LAC @ Chi |
| 47 | Carlos Hyde | Hou vs Oak |
| 48 | Josh Jacobs (que) | Oak @ Hou |
| 49 | Alshon Jeffery | Phi @ Buf |
| 50 | Marquez Valdes-Scantling (GTD) | GB @ KC |
| 51 | Calvin Ridley | Atl vs Sea |
| 52 | Zach Ertz | Phi @ Buf |
| 53 | Brandin Cooks | LAR @ Cin |
| 54 | Hunter Henry | LAC @ Chi |
| 55 | Larry Fitzgerald | Ari @ NO |
| 56 | Golden Tate | NYG @ Det |
| 57 | David Montgomery | Chi vs LAC |
| 58 | D.J. Moore | Car @ SF |
| 59 | Melvin Gordon | LAC @ Chi |
| 60 | Kenny Stills | Hou vs Oak |
| 61 | D.K. Metcalf | Sea @ Atl |
| 62 | Curtis Samuel | Car @ SF |
| 63 | Dede Westbrook (que) | Jax vs NYJ |
| 64 | Joe Mixon | Cin vs LAR |
| 65 | Tyrell Williams (que) | Oak @ Hou |
| 66 | Jamison Crowder (GTD) | NYJ @ Jax |
| 67 | Royce Freeman | Den @ Ind |
| 68 | Matt Breida | SF vs Car |
| 69 | LeSean McCoy | KC vs GB |
| 70 | Mike Williams | LAC @ Chi |
