All position rankings are: QB | RB | WR | TE | FLEX | D
These rankings were updated as of Sun 9:28 AM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | Car vs Jax |
| 2 | Alvin Kamara | NO vs TB |
| 3 | Ezekiel Elliott | Dal vs GB |
| 4 | Dalvin Cook | Min @ NYG |
| 5 | David Johnson | Ari @ Cin |
| 6 | Nick Chubb | Cle @ SF |
| 7 | Le'Veon Bell | NYJ @ Phi |
| 8 | Leonard Fournette | Jax @ Car |
| 9 | Aaron Jones | GB @ Dal |
| 10 | Austin Ekeler | LAC vs Den |
| 11 | Joe Mixon | Cin vs Ari |
| 12 | Derrick Henry | Ten vs Buf |
| 13 | James Conner | Pit vs Bal |
| 14 | Sony Michel | NE @ Wsh |
| 15 | Devonta Freeman | Atl @ Hou |
| 16 | David Montgomery | Chi vs Oak |
| 17 | Marlon Mack (que) | Ind @ KC |
| 18 | Wayne Gallman (GTD) | NYG vs Min |
| 19 | Mark Ingram | Bal @ Pit |
| 20 | James White | NE @ Wsh |
| Rank | Player | Match |
| 21 | Melvin Gordon | LAC vs Den |
| 22 | Phillip Lindsay | Den @ LAC |
| 23 | LeSean McCoy (GTD) | KC vs Ind |
| 24 | Josh Jacobs (GTD) | Oak @ Chi |
| 25 | Damien Williams (que) | KC vs Ind |
| 26 | Carlos Hyde | Hou vs Atl |
| 27 | Jordan Howard | Phi vs NYJ |
| 28 | Chris Thompson | Wsh vs NE |
| 29 | Royce Freeman | Den @ LAC |
| 30 | Matt Breida | SF vs Cle |
| 31 | Duke Johnson | Hou vs Atl |
| 32 | Miles Sanders | Phi vs NYJ |
| 33 | Tarik Cohen | Chi vs Oak |
| 34 | Frank Gore | Buf @ Ten |
| 35 | Ronald Jones | TB @ NO |
| 36 | Jaylen Samuels | Pit vs Bal |
| 37 | Peyton Barber | TB @ NO |
| 38 | Adrian Peterson | Wsh vs NE |
| 39 | Dion Lewis | Ten vs Buf |
| 40 | Raheem Mostert | SF vs Cle |
