All position rankings are: QB | RB | WR | TE | FLEX | D
These rankings were updated as of Sun 9:28 AM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | Car vs Jax |
| 2 | Alvin Kamara | NO vs TB |
| 3 | Ezekiel Elliott | Dal vs GB |
| 4 | Dalvin Cook | Min @ NYG |
| 5 | David Johnson | Ari @ Cin |
| 6 | Nick Chubb | Cle @ SF |
| 7 | DeAndre Hopkins | Hou vs Atl |
| 8 | Le'Veon Bell | NYJ @ Phi |
| 9 | Julio Jones | Atl @ Hou |
| 10 | Keenan Allen | LAC vs Den |
| 11 | Leonard Fournette | Jax @ Car |
| 12 | Travis Kelce | KC vs Ind |
| 13 | Michael Thomas | NO vs TB |
| 14 | Aaron Jones | GB @ Dal |
| 15 | Austin Ekeler | LAC vs Den |
| 16 | Joe Mixon | Cin vs Ari |
| 17 | Odell Beckham | Cle @ SF |
| 18 | Chris Godwin | TB @ NO |
| 19 | Derrick Henry | Ten vs Buf |
| 20 | Amari Cooper | Dal vs GB |
| 21 | Tyler Boyd | Cin vs Ari |
| 22 | James Conner | Pit vs Bal |
| 23 | Mike Evans | TB @ NO |
| 24 | Sammy Watkins (que) | KC vs Ind |
| 25 | T.Y. Hilton (que) | Ind @ KC |
| 26 | Julian Edelman (que) | NE @ Wsh |
| 27 | Sony Michel | NE @ Wsh |
| 28 | Devonta Freeman | Atl @ Hou |
| 29 | David Montgomery | Chi vs Oak |
| 30 | Marlon Mack (que) | Ind @ KC |
| 31 | Adam Thielen | Min @ NYG |
| 32 | Larry Fitzgerald | Ari @ Cin |
| 33 | George Kittle | SF vs Cle |
| 34 | Zach Ertz | Phi vs NYJ |
| 35 | Wayne Gallman (GTD) | NYG vs Min |
| Rank | Player | Match |
| 36 | Mark Ingram | Bal @ Pit |
| 37 | James White | NE @ Wsh |
| 38 | JuJu Smith-Schuster (que) | Pit vs Bal |
| 39 | Melvin Gordon | LAC vs Den |
| 40 | Phillip Lindsay | Den @ LAC |
| 41 | Alshon Jeffery | Phi vs NYJ |
| 42 | Josh Gordon | NE @ Wsh |
| 43 | Allen Robinson | Chi vs Oak |
| 44 | Marquez Valdes-Scantling | GB @ Dal |
| 45 | Evan Engram | NYG vs Min |
| 46 | Stefon Diggs | Min @ NYG |
| 47 | LeSean McCoy (GTD) | KC vs Ind |
| 48 | Sterling Shepard | NYG vs Min |
| 49 | Courtland Sutton | Den @ LAC |
| 50 | Emmanuel Sanders | Den @ LAC |
| 51 | Josh Jacobs (GTD) | Oak @ Chi |
| 52 | Damien Williams (que) | KC vs Ind |
| 53 | Marquise Brown | Bal @ Pit |
| 54 | D.J. Moore | Car vs Jax |
| 55 | Calvin Ridley | Atl @ Hou |
| 56 | Jarvis Landry | Cle @ SF |
| 57 | Carlos Hyde | Hou vs Atl |
| 58 | Darren Waller | Oak @ Chi |
| 59 | Jordan Howard | Phi vs NYJ |
| 60 | Curtis Samuel | Car vs Jax |
| 61 | Will Fuller | Hou vs Atl |
| 62 | John Brown | Buf @ Ten |
| 63 | Mike Williams (que) | LAC vs Den |
| 64 | Mark Andrews | Bal @ Pit |
| 65 | Chris Thompson | Wsh vs NE |
| 66 | Demarcus Robinson | KC vs Ind |
| 67 | Austin Hooper | Atl @ Hou |
| 68 | D.J. Chark | Jax @ Car |
| 69 | Tyrell Williams (que) | Oak @ Chi |
| 70 | Royce Freeman | Den @ LAC |
