All position rankings are: QB | RB | WR | TE | FLEX | D
These rankings were updated as of Sun 9:47 AM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | Car @ Hou |
| 2 | Austin Ekeler | LAC @ Mia |
| 3 | Alvin Kamara | NO vs Dal |
| 4 | Ezekiel Elliott | Dal @ NO |
| 5 | Dalvin Cook | Min @ Chi |
| 6 | James Conner | Pit vs Cin |
| 7 | David Johnson | Ari vs Sea |
| 8 | Leonard Fournette | Jax @ Den |
| 9 | Nick Chubb | Cle @ Bal |
| 10 | Marlon Mack | Ind vs Oak |
| 11 | Chris Carson | Sea @ Ari |
| 12 | Todd Gurley | LAR vs TB |
| 13 | Kerryon Johnson | Det vs KC |
| 14 | Derrick Henry | Ten @ Atl |
| 15 | Mark Ingram | Bal vs Cle |
| 16 | Devonta Freeman | Atl vs Ten |
| 17 | Phillip Lindsay | Den vs Jax |
| 18 | Joe Mixon | Cin @ Pit |
| 19 | Wayne Gallman | NYG vs Wsh |
| 20 | Josh Jacobs | Oak @ Ind |
| Rank | Player | Match |
| 21 | David Montgomery | Chi vs Min |
| 22 | LeSean McCoy (GTD) | KC @ Det |
| 23 | Sony Michel | NE @ Buf |
| 24 | Chris Thompson | Wsh @ NYG |
| 25 | Kenyan Drake | Mia vs LAC |
| 26 | Carlos Hyde | Hou vs Car |
| 27 | James White (GTD) | NE @ Buf |
| 28 | Adrian Peterson | Wsh @ NYG |
| 29 | Royce Freeman | Den vs Jax |
| 30 | Duke Johnson | Hou vs Car |
| 31 | Peyton Barber | TB @ LAR |
| 32 | Frank Gore | Buf vs NE |
| 33 | Tarik Cohen | Chi vs Min |
| 34 | Rex Burkhead (que) | NE @ Buf |
| 35 | Darrel Williams | KC @ Det |
| 36 | Ronald Jones | TB @ LAR |
| 37 | Giovani Bernard | Cin @ Pit |
| 38 | Kalen Ballage | Mia vs LAC |
| 39 | Rashaad Penny (que) | Sea @ Ari |
| 40 | Devin Singletary (que) | Buf vs NE |
