These standard ranks are updated as of Nov. 24
Other Week 12 Ranks: Top 20 QBs Top 50 WRs Top 20 TEs
| Rank | Player | Team | Opp |
| 1 | James Conner | PIT | @DEN |
| 2 | Nick Chubb | CLE | @CIN |
| 3 | Christian McCaffrey | CAR | SEA |
| 4 | Saquon Barkley | NYG | @PHI |
| 5 | Joe Mixon | CIN | CLE |
| 6 | David Johnson | ARI | @LAC |
| 7 | Leonard Fournette | JAX | @BUF |
| 8 | James White | NE | @NYJ |
| 9 | Aaron Jones | GB | @MIN |
| 10 | Marlon Mack | IND | MIA |
| 11 | Dalvin Cook | MIN | GB |
| 12 | Phillip Lindsay | DEN | PIT |
| 13 | Matt Breida | SF | @TB |
| 14 | Sony Michel | NE | @NYJ |
| 15 | Tevin Coleman | ATL | @NO |
| 16 | Melvin Gordon | LAC | ARI |
| 17 | Lamar Miller | HOU | TEN |
| 18 | Chris Carson | SEA | @CAR |
| 19 | Josh Adams | PHI | NYG |
| 20 | LeSean McCoy | BUF | JAX |
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| Rank | Player | Team | Opp |
| 21 | Dion Lewis | TEN | @HOU |
| 22 | Austin Ekeler | LAC | ARI |
| 23 | Duke Johnson Jr | CLE | @CIN |
| 24 | Kenyan Drake | MIA | @IND |
| 25 | Gus Edwards | BAL | OAK |
| 26 | Jalen Richard | OAK | @BAL |
| 27 | Peyton Barber | TB | SF |
| 28 | Alex Collins | BAL | OAK |
| 29 | Isaiah Crowell | NYJ | NE |
| 30 | Frank Gore | MIA | @IND |
| 31 | Nyheim Hines | IND | MIA |
| 32 | Royce Freeman | DEN | PIT |
| 33 | Doug Martin | OAK | @BAL |
| 34 | Elijah McGuire | NYJ | NE |
| 35 | T.J. Yeldon | JAX | @BUF |
| 36 | Rashaad Penny | SEA | @CAR |
| 37 | Alfred Blue | HOU | TEN |
| 38 | Wendall Smallwood | PHI | NYG |
| 39 | Latavius Murray | MIN | GB |
| 40 | Chris Ivory | BUF | JAX |
*Assuming the player plays
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