Also look at these other Week 6 rankings: QB RB WR TE
These ranks are updated as of Oct. 12 and will be updated throughout the weekend.
On bye: Bengals, Bills, Cowboys, Seahawks
| Rank | Player | Pos | Team | Opp |
| 1 | Kareem Hunt | RB | KC | PIT |
| 2 | Antonio Brown | WR | PIT | @KC |
| 3 | Le'Veon Bell | RB | PIT | @KC |
| 4 | Leonard Fournette | RB | JAC | LAR |
| 5 | Todd Gurley | RB | LAR | @JAC |
| 6 | Melvin Gordan | RB | LAC | @OAK |
| 7 | Julio Jones | WR | ATL | MIA |
| 8 | DeAndre Hopkins | WR | HOU | CLE |
| 9 | Devonta Freeman | RB | ATL | MIA |
| 10 | Jordy Nelson | WR | GB | @MIN |
| 11 | Michael Thomas | WR | NO | DET |
| 12 | Rob Gronkowski | TE | NE | @NYJ |
| 13 | C.J. Anderson | RB | DEN | NYG |
| 14 | Brandin Cooks | WR | NE | @NYJ |
| 15 | Keenan Allen | WR | LAC | @OAK |
| 16 | Alvin Kamara | RB | NO | DET |
| 17 | Travis Kelce | TE | KC | PIT |
| 18 | Tyreek Hill | WR | KC | PIT |
| 19 | Golden Tate | WR | DET | @NO |
| 20 | Jarvis Landry | WR | MIA | @ATL |
| 21 | Jerick McKinnon | RB | MIN | GB |
| 22 | Jay Ajayi | RB | MIA | @ATL |
| 23 | Christian McCaffrey | RB | CAR | PHI |
| 24 | Michael Crabtree | WR | OAK | LAC |
| 25 | Mike Evans | WR | TB | @ARI |
| 26 | Javorius Allen | RB | BAL | CHI |
| 27 | Lamar Miller | RB | HOU | CLE |
| 28 | Chris Hogan | WR | NE | @NYJ |
| 29 | T.Y. Hilton | WR | IND | @TEN |
| 30 | Jordan Howard | RB | CHI | @BAL |
| 31 | Davante Adams | WR | GB | @MIN |
| 32 | Kelvin Benjamin | WR | CAR | PHI |
| 33 | DeVante Parker | WR | MIA | @ATL |
| 34 | Ameer Abdullah | RB | DET | @NO |
| 35 | Willie Snead | WR | NO | DET |
| 36 | Emmanuel Sanders | WR | DEN | NYG |
| 37 | Carlos Hyde | RB | SF | @WAS |
| 38 | Adam Thielen | WR | MIN | GB |
| 39 | Mark Ingram | RB | NO | DET |
| 40 | Larry Fitzgerald | WR | ARI | TB |
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| Rank | Player | Pos. | Team | Opp. |
| 41 | Delanie Walker | TE | TEN | IND |
| 42 | DeMarco Murray | RB | TEN | IND |
| 43 | Demaryius Thomas | WR | DEN | NYG |
| 44 | DeSean Jackson | WR | TB | @ARI |
| 45 | Terrelle Pryor | WR | WAS | SF |
| 46 | Will Fuller | WR | HOU | CLE |
| 47 | Doug Martin | RB | TB | @ARI |
| 48 | Amari Cooper | WR | OAK | LAC |
| 49 | Allen Hurns | WR | JAC | LAR |
| 50 | Marshawn Lynch | RB | OAK | LAC |
| 51 | Cooper Kupp | WR | LAR | @JAC |
| 52 | James White | RB | NE | NYJ |
| 53 | Jordan Reed | TE | WAS | SF |
| 54 | Chris Thompson | RB | WAS | SF |
| 55 | Rishard Matthews | WR | TEN | IND |
| 56 | Adrian Peterson | RB | ARI | TB |
| 57 | Will Fuller | WR | HOU | CLE |
| 58 | Andre Ellington | RB | ARI | TB |
| 59 | Tevin Coleman | RB | ATL | MIA |
| 60 | Aaron Jones | RB | GB | @MIN |
| 61 | Tyrell Williams | WR | LAC | @OAK |
| 62 | Randall Cobb | WR | GB | @MIN |
| 63 | Elijah McGuire | RB | NYJ | NE |
| 64 | Jeremy Maclin | WR | BAL | CHI |
| 65 | Tarik Cohen | RB | CHI | @BAL |
| 66 | Duke Johnson | RB | CLE | @HOU |
| 67 | Devin Funchess | WR | CAR | PHI |
| 68 | Alex Collins | RB | BAL | CHI |
| 69 | Cameron Brate | TE | TB | @ARI |
| 70 | Mike Wallace | WR | BAL | CHI |
| 71 | Evan Engram | TE | NYG | @DEN |
| 72 | J.J. Nelson | WR | ARI | TB |
| 73 | Wayne Gallman | RB | NYG | @DEN |
| 74 | Jermaine Kearse | WR | NYJ | NE |
| 75 | Sammy Watkins | WR | LAR | @JAC |
| 76 | Kyle Rudolph | TE | MIN | GB |
| 77 | Marlon Mack | RB | IND | @TEN |
| 78 | Matt Breida | RB | SF | @WAS |
| 79 | JuJu Smith-Schuster | WR | PIT | @KC |
| 80 | Austin Seferian-Jenkins | TE | NYJ | NE |
| 81 | Taylor Gabriel | WR | ATL | MIA |
| 82 | Marvin Jones Jr. | WR | DET | NO |
| 83 | Samaji Perine | RB | WAS | SF |
| 84 | Jonathan Stewart | RB | CAR | @DET |
| 85 | Isaiah Crowell | RB | CLE | HOU |
