All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sat 9:13 AM ET.
| Rank | Player | Match |
| 1 | Alvin Kamara | NO @ Car |
| 2 | Kyren Williams | LAR @ Sea |
| 3 | Saquon Barkley | Phi vs Jax |
| 4 | Bijan Robinson | Atl vs Dal |
| 5 | Derrick Henry | Bal vs Den |
| 6 | Aaron Jones | Min vs Ind |
| 7 | Jahmyr Gibbs | Det @ GB |
| 8 | Kenneth Walker III | Sea vs LAR |
| 9 | Jonathan Taylor | Ind @ Min |
| 10 | De'Von Achane | Mia @ Buf |
| 11 | Kareem Hunt (P) | KC vs TB |
| 12 | J.K. Dobbins | LAC @ Cle |
| 13 | Tony Pollard (Q) | Ten vs NE |
| 14 | Chase Brown | Cin vs LV |
| 15 | D'Andre Swift | Chi @ Ari |
| 16 | James Conner | Ari vs Chi |
| 17 | James Cook | Buf vs Mia |
| 18 | Josh Jacobs (Q) | GB vs Det |
| 19 | Chuba Hubbard | Car vs NO |
| 20 | David Montgomery | Det @ GB |
| Rank | Player | Match |
| 21 | Nick Chubb | Cle vs LAC |
| 22 | Alexander Mattison | LV @ Cin |
| 23 | Rhamondre Stevenson | NE @ Ten |
| 24 | Tyrone Tracy Jr. | NYG vs Wsh |
| 25 | Brian Robinson (Q) | Wsh @ NYG |
| 26 | Javonte Williams | Den @ Bal |
| 27 | Rico Dowdle | Dal @ Atl |
| 28 | Tank Bigsby (Q) | Jax @ Phi |
| 29 | Rachaad White | TB @ KC |
| 30 | Bucky Irving (Q) | TB @ KC |
| 31 | Austin Ekeler | Wsh @ NYG |
| 32 | Raheem Mostert | Mia @ Buf |
| 33 | Tyler Allgeier | Atl vs Dal |
| 34 | Travis Etienne (Q) | Jax @ Phi |
| 35 | Zach Charbonnet | Sea vs LAR |
| 36 | Devin Singletary | NYG vs Wsh |
| 37 | Jerome Ford | Cle vs LAC |
| 38 | Ezekiel Elliott | Dal @ Atl |
| 39 | Roschon Johnson | Chi @ Ari |
| 40 | Antonio Gibson | NE @ Ten |
