All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sat 9:27 AM ET.
| Rank | Player | Match |
| 1 | Joe Mixon | Hou vs Ind |
| 2 | Derrick Henry | Bal @ Cle |
| 3 | Breece Hall | NYJ vs Hou |
| 4 | Saquon Barkley | Phi @ Cin |
| 5 | Ja'Marr Chase | Cin vs Phi |
| 6 | Amon-Ra St. Brown | Det vs Ten |
| 7 | Bijan Robinson | Atl @ TB |
| 8 | Jahmyr Gibbs | Det vs Ten |
| 9 | J.K. Dobbins | LAC vs NO |
| 10 | Kenneth Walker III | Sea vs Buf |
| 11 | Tyreek Hill (Q) | Mia vs Ari |
| 12 | A.J. Brown | Phi @ Cin |
| 13 | CeeDee Lamb | Dal @ SF |
| 14 | Kareem Hunt | KC @ LV |
| 15 | Stefon Diggs | Hou vs Ind |
| 16 | De'Von Achane | Mia vs Ari |
| 17 | Drake London | Atl @ TB |
| 18 | Alvin Kamara | NO @ LAC |
| 19 | Jordan Mason | SF vs Dal |
| 20 | Malik Nabers | NYG @ Pit |
| 21 | George Kittle (Q) | SF vs Dal |
| 22 | Josh Jacobs | GB @ Jax |
| 23 | Jayden Reed | GB @ Jax |
| 24 | Najee Harris | Pit vs NYG |
| 25 | Deebo Samuel (Q) | SF vs Dal |
| 26 | Tony Pollard | Ten @ Det |
| 27 | Tee Higgins (Q) | Cin vs Phi |
| 28 | James Conner | Ari @ Mia |
| 29 | George Pickens | Pit vs NYG |
| 30 | Javonte Williams | Den vs Car |
| 31 | Davante Adams | NYJ vs Hou |
| 32 | D'Andre Swift | Chi @ Wsh |
| 33 | David Montgomery | Det vs Ten |
| 34 | James Cook | Buf @ Sea |
| 35 | Chuba Hubbard | Car @ Den |
| Rank | Player | Match |
| 36 | DJ Moore | Chi @ Wsh |
| 37 | Garrett Wilson | NYJ vs Hou |
| 38 | Jonathan Taylor | Ind @ Hou |
| 39 | Terry McLaurin | Wsh vs Chi |
| 40 | DeVonta Smith | Phi @ Cin |
| 41 | Tank Dell | Hou vs Ind |
| 42 | Chase Brown | Cin vs Phi |
| 43 | Brian Thomas Jr. | Jax vs GB |
| 44 | Amari Cooper | Buf @ Sea |
| 45 | Rico Dowdle | Dal @ SF |
| 46 | Travis Kelce | KC @ LV |
| 47 | Jaylen Waddle | Mia vs Ari |
| 48 | Zay Flowers (Q) | Bal @ Cle |
| 49 | Brian Robinson Jr. | Wsh vs Chi |
| 50 | David Njoku | Cle vs Bal |
| 51 | Rhamondre Stevenson | NE vs NYJ |
| 52 | Brock Bowers | LV vs KC |
| 53 | Nick Chubb | Cle vs Bal |
| 54 | Alexander Mattison | LV vs KC |
| 55 | Courtland Sutton | Den vs Car |
| 56 | Trey McBride | Ari @ Mia |
| 57 | Darnell Mooney | Atl @ TB |
| 58 | Tank Bigsby | Jax vs GB |
| 59 | Rachaad White | TB vs Atl |
| 60 | Marvin Harrison Jr. | Ari @ Mia |
| 61 | Chris Olave | NO @ LAC |
| 62 | Ladd McConkey (Q) | LAC vs NO |
| 63 | Tyler Lockett | Sea vs Buf |
| 64 | Evan Engram | Jax vs GB |
| 65 | Romeo Doubs | GB @ Jax |
| 66 | Jaxon Smith-Njigba | Sea vs Buf |
| 67 | Xavier Worthy | KC @ LV |
| 68 | Wan'Dale Robinson | NYG @ Pit |
| 69 | Christian Kirk | Jax vs GB |
| 70 | Jalen McMillan | TB vs Atl |
