All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sat 9:26 AM ET.
| Rank | Player | Match |
| 1 | Joe Mixon | Hou vs Ind |
| 2 | Derrick Henry | Bal @ Cle |
| 3 | Breece Hall | NYJ vs Hou |
| 4 | Saquon Barkley | Phi @ Cin |
| 5 | Bijan Robinson | Atl @ TB |
| 6 | Jahmyr Gibbs | Det vs Ten |
| 7 | J.K. Dobbins | LAC vs NO |
| 8 | Kenneth Walker III | Sea vs Buf |
| 9 | Kareem Hunt | KC @ LV |
| 10 | De'Von Achane | Mia vs Ari |
| 11 | Alvin Kamara | NO @ LAC |
| 12 | Jordan Mason | SF vs Dal |
| 13 | Josh Jacobs | GB @ Jax |
| 14 | Najee Harris | Pit vs NYG |
| 15 | Tony Pollard | Ten @ Det |
| 16 | James Conner | Ari @ Mia |
| 17 | Javonte Williams | Den vs Car |
| 18 | D'Andre Swift | Chi @ Wsh |
| 19 | David Montgomery | Det vs Ten |
| 20 | James Cook | Buf @ Sea |
| Rank | Player | Match |
| 21 | Chuba Hubbard | Car @ Den |
| 22 | Jonathan Taylor | Ind @ Hou |
| 23 | Chase Brown | Cin vs Phi |
| 24 | Rico Dowdle | Dal @ SF |
| 25 | Brian Robinson Jr. | Wsh vs Chi |
| 26 | Rhamondre Stevenson | NE vs NYJ |
| 27 | Nick Chubb | Cle vs Bal |
| 28 | Alexander Mattison | LV vs KC |
| 29 | Tank Bigsby | Jax vs GB |
| 30 | Rachaad White | TB vs Atl |
| 31 | Raheem Mostert | Mia vs Ari |
| 32 | Zack Moss | Cin vs Phi |
| 33 | Bucky Irving (Q) | TB vs Atl |
| 34 | Austin Ekeler | Wsh vs Chi |
| 35 | Travis Etienne (Q) | Jax vs GB |
| 36 | Jaylen Warren | Pit vs NYG |
| 37 | Tyrone Tracy Jr. | NYG @ Pit |
| 38 | Tyler Allgeier | Atl @ TB |
| 39 | Devin Singletary | NYG @ Pit |
| 40 | Jaleel McLaughlin | Den vs Car |
