All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sat 9:46 AM ET.
| Rank | Player | Match |
| 1 | Kyren Williams | LAR vs LV |
| 2 | Derrick Henry | Bal @ TB |
| 3 | Saquon Barkley | Phi @ NYG |
| 4 | J.K. Dobbins | LAC @ Ari |
| 5 | Bijan Robinson | Atl vs Sea |
| 6 | Kenneth Walker | Sea @ Atl |
| 7 | Chuba Hubbard | Car @ Wsh |
| 8 | Breece Hall | NYJ @ Pit |
| 9 | Joe Mixon | Hou @ GB |
| 10 | Tony Pollard | Ten @ Buf |
| 11 | Jahmyr Gibbs | Det @ Min |
| 12 | Josh Jacobs | GB vs Hou |
| 13 | Aaron Jones (Q) | Min vs Det |
| 14 | James Conner | Ari vs LAC |
| 15 | James Cook | Buf vs Ten |
| 16 | Brian Robinson Jr. (Q) | Wsh vs Car |
| 17 | De'Von Achane | Mia @ Ind |
| 18 | David Montgomery | Det @ Min |
| 19 | Najee Harris | Pit vs NYJ |
| 20 | Kareem Hunt | KC @ SF |
| Rank | Player | Match |
| 21 | Chase Brown | Cin @ Cle |
| 22 | Austin Ekeler | Wsh vs Car |
| 23 | Jordan Mason | SF vs KC |
| 24 | Bucky Irving | TB vs Bal |
| 25 | Nick Chubb (Q) | Cle vs Cin |
| 26 | Tank Bigsby | Jax vs NE |
| 27 | Alexander Mattison | LV @ LAR |
| 28 | Devin Singletary | NYG vs Phi |
| 29 | Rhamondre Stevenson (Q) | NE @ Jax |
| 30 | Tyler Allgeier | Atl vs Sea |
| 31 | Zack Moss | Cin @ Cle |
| 32 | Antonio Gibson | NE @ Jax |
| 33 | Tyrone Tracy | NYG vs Phi |
| 34 | Raheem Mostert | Mia @ Ind |
| 35 | Ty Chandler | Min vs Det |
| 36 | Trey Sermon | Ind vs Mia |
| 37 | Travis Etienne (Q) | Jax vs NE |
| 38 | D'Ernest Johnson | Jax vs NE |
| 39 | Jaylen Warren | Pit vs NYJ |
| 40 | Rachaad White (Q) | TB vs Bal |
