All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sat 9:46 AM ET.
| Rank | Player | Match |
| 1 | Kyren Williams | LAR vs GB |
| 2 | Derrick Henry | Bal @ Cin |
| 3 | Jordan Mason | SF vs Ari |
| 4 | Alvin Kamara (Q) | NO @ KC |
| 5 | Kenneth Walker III | Sea vs NYG |
| 6 | De'Von Achane | Mia @ NE |
| 7 | Chuba Hubbard | Car @ Chi |
| 8 | Najee Harris | Pit vs Dal |
| 9 | Josh Jacobs | GB @ LAR |
| 10 | James Conner | Ari @ SF |
| 11 | Brian Robinson Jr. (Q) | Wsh vs Cle |
| 12 | James Cook | Buf @ Hou |
| 13 | Travis Etienne Jr. | Jax vs Ind |
| 14 | Zack Moss | Cin vs Bal |
| 15 | Jerome Ford | Cle @ Wsh |
| 16 | D'Andre Swift | Chi vs Car |
| 17 | Rhamondre Stevenson | NE vs Mia |
| 18 | Javonte Williams | Den vs LV |
| 19 | Alexander Mattison | LV @ Den |
| 20 | Tyrone Tracy Jr. | NYG @ Sea |
| Rank | Player | Match |
| 21 | Rico Dowdle | Dal @ Pit |
| 22 | Cam Akers | Hou vs Buf |
| 23 | Austin Ekeler | Wsh vs Cle |
| 24 | Antonio Gibson | NE vs Mia |
| 25 | Chase Brown | Cin vs Bal |
| 26 | Trey Sermon | Ind @ Jax |
| 27 | Kareem Hunt (Q) | KC vs NO |
| 28 | Justice Hill | Bal @ Cin |
| 29 | Roschon Johnson | Chi vs Car |
| 30 | Zach Charbonnet | Sea vs NYG |
| 31 | Jaleel McLaughlin | Den vs LV |
| 32 | Emanuel Wilson | GB @ LAR |
| 33 | Samaje Perine | KC vs NO |
| 34 | Miles Sanders | Car @ Chi |
| 35 | Dare Ogunbowale | Hou vs Buf |
| 36 | Tank Bigsby | Jax vs Ind |
| 37 | Tyler Goodson | Ind @ Jax |
| 38 | Raheem Mostert | Mia @ NE |
| 39 | Ezekiel Elliott | Dal @ Pit |
| 40 | Carson Steele | KC vs NO |
